Document Detail

Effects of CO2 on dynamic cerebral autoregulation measurement.
MedLine Citation:
PMID:  10475580     Owner:  NLM     Status:  MEDLINE    
Arterial pCO2 is known to influence cerebral autoregulation but its effect on the dynamic relationship between mean arterial blood pressure (ABP) and mean cerebral blood flow velocity (CBFV), obtained from spontaneous fluctuations in ABP, has not been established. In 16 normal subjects, ABP was measured non-invasively (Finapres), CBFV was estimated with Doppler ultrasound in the middle cerebral artery, and end-tidal CO2 (EtCO2) was measured with an infrared capnograph. Recordings were made before, during and after breathing a mixture of 5% CO2 in air. The coherence function, amplitude and phase frequency responses, and impulse and step responses for the effects of ABP on CBFV were calculated by spectral analysis of beat-to-beat changes in mean ABP and CBFV before (mean CO2 5.55 +/- 0.38 kPa), during (6.43 +/- 0.31 kPa) and after 5% CO2 (5.43 +/- 0.26 kPa). During 5% CO2, the coherence function and the amplitude frequency response were significantly increased for frequencies below 0.05 Hz and the phase was reduced for the frequency range 0.02-0.1 Hz. The impulse and step responses indicated that 5% CO2 reduces the efficiency of the autoregulatory mechanism. A 20.7% average increase in CBFV induced by a 14.4% increase in EtCO2 was found to be mediated by a 25.9% reduction in critical closing pressure, while the change in resistance area product was non-significant.
R B Panerai; S T Deverson; P Mahony; P Hayes; D H Evans
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiological measurement     Volume:  20     ISSN:  0967-3334     ISO Abbreviation:  Physiol Meas     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-10-08     Completed Date:  1999-10-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9306921     Medline TA:  Physiol Meas     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  265-75     Citation Subset:  IM    
Division of Medical Physics, Faculty of Medicine, University of Leicester, Leicester Royal Infirmary, UK.
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MeSH Terms
Blood Flow Velocity
Blood Pressure / drug effects
Brain / blood supply*
Carbon Dioxide / blood*,  pharmacology
Cerebral Arteries / ultrasonography
Heart Rate / drug effects
Middle Aged
Regional Blood Flow
Reg. No./Substance:
124-38-9/Carbon Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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