Document Detail


Effects of CI-914 in congestive heart failure due to coronary artery disease or idiopathic cardiomyopathy.
MedLine Citation:
PMID:  3751929     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hemodynamic effects of CI-914, a phosphodiesterase inhibitor, were studied in 12 patients with left ventricular (LV) dysfunction who were undergoing diagnostic cardiac catheterization. CI-914 was infused intravenously at a rate of 0.8 to 7.0 micrograms/kg/min for 30 to 60 minutes; hemodynamic values were measured every 10 minutes. No effect was seen in the patient receiving 0.8 microgram/kg/min. At infusion rates of 1.2 to 2.4 micrograms/kg/min, cardiac index increased by 14% (p less than 0.025). At infusion rates of 4.5 to 7.0 micrograms/kg/min, cardiac index increased by 21% (n = 8, difference not significant [NS]). Among 4 patients (group B) with an initial pulmonary artery wedge pressure greater than 20 mm Hg and cardiac index less than 2.5 liters/min/m2, cardiac index increased by 50% (p less than 0.001); it did not change among the 4 patients with an initial pulmonary artery wedge pressure of less than 20 mm Hg and cardiac index of more than 2.5 liters/min/m2 (group A). Although systemic vascular resistance decreased in all 8 patients by 26% (p less than 0.01), the reduction was greater in group B (33%, p less than 0.01) than in group A (16%, NS). Peak +dP/dt increased in all 8 patients by 13% (p less than 0.01). Mean stroke work index increased from 29 +/- 15 to 34 +/- 13 g-m/m2; the double product fell from 101 +/- 31 to 91 +/- 23 (NS). In all 12 patients, a linear correlation between peak venous blood concentration and peak effect on cardiac index, systemic vascular resistance and pulmonary artery wedge pressure was observed.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
S Terris; P D Bourdillon; D Cheng; J Latts; S Olsen; J Nicklas; B Pitt
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  58     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-10-20     Completed Date:  1986-10-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  596-600     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Cardiac Output / drug effects
Cardiotonic Agents / pharmacology*
Coronary Disease / complications
Female
Heart Failure / blood,  etiology,  physiopathology*
Hemodynamics / drug effects*
Humans
Male
Middle Aged
Pulmonary Wedge Pressure
Pyridazines / blood,  pharmacology*
Vascular Resistance / drug effects
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 0/Pyridazines; 84243-58-3/imazodan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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