Document Detail


Effects of CD-832, a new calcium antagonist, on intracranial pressure in anesthetized dogs.
MedLine Citation:
PMID:  9585114     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Effects of a new calcium antagonist, CD-832, on intracranial pressure (ICP), vertebral blood flow (VBF) and common carotid blood flow (CCBF) were investigated in dogs and the results were compared with findings for nifedipine and diltiaem. Dogs were anesthetized with sodium pentobarbital and a 20-gauge needle was inserted into the cisterna magna for ICP determination. Mean arterial blood pressure (MBP), heart rate (HR), CP, VBF and CCBF were measured before and during the continuous intravenous infusion of CD-832 (0.3, 1 and 3 microg/kg/min), nifedipine (0.1, 0.3 and 1 microg/kg/min) or diltiazem (1, 3 and 10 microg/kg/min). Although the three drugs caused a comparable hypotension, differences were evident in effects of these agents on ICP, VBF and CCBF. Nifedipine and diltiazem but not CD-832 significantly increased ICP, VBF and CCBF. These results suggest that CD-832 is a unique calcium antagonist which does not increase ICP during hypotension. Because the most evident side effects of calcium antagonists are caused by vasodilation and include headache and flushing, CD-832 may possibly be useful to treat subjects with hypertension or angina pectoris.
Authors:
T Takahashi; S Tanikawa; T Ota; K Takahashi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  62     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  1998  
Date Detail:
Created Date:  1998-05-19     Completed Date:  1998-05-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  PL283-8     Citation Subset:  IM    
Affiliation:
Medicinal Research Laboratories, Taisho Pharmaceutical Co., Ltd., Ohmiya, Saitama, Japan. s14835@ccm.taisho.co.jp
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MeSH Terms
Descriptor/Qualifier:
Anesthesia
Animals
Blood Pressure / drug effects
Calcium Channel Blockers / chemistry,  pharmacology*
Dogs
Dose-Response Relationship, Drug
Female
Heart Rate / drug effects
Intracranial Pressure / drug effects*
Male
Niacinamide / analogs & derivatives*,  chemistry,  pharmacology
Nifedipine / analogs & derivatives*,  chemistry,  pharmacology
Regional Blood Flow / drug effects
Chemical
Reg. No./Substance:
0/CD 832; 0/Calcium Channel Blockers; 21829-25-4/Nifedipine; 98-92-0/Niacinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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