Document Detail

Effects of the CCK receptor antagonist MK-329 on food intake in broiler chickens.
MedLine Citation:
PMID:  8090818     Owner:  NLM     Status:  MEDLINE    
The cholecystokinin (CCK) receptor antagonist MK-329 (previously L-364,718) was administered intraperitoneally to free-feeding broiler chickens and tested for conditioning effects using the colored food paradigm. The 8.0, 16.0, and 32.0 micrograms/kg doses of MK-329 did not exert any effect on food intake and failed to condition a color preference or aversion. When higher doses were used (90, 180, and 360 micrograms/kg) MK-329 caused a significant increase in food intake during the 2-h test period. Intravenously injected MK-329 (70, 140, and 280 micrograms/kg) produced an increase in food intake, with maximum increases occurring at a dose of 70 micrograms/kg. CCK (14 micrograms/kg) caused a reduction in feeding, and this effect was not blocked by pretreatment with intraperitoneal injection of MK-329 (32, 90, 180, and 360 micrograms/kg). The results question the role of endogenous CCK in satiety in chickens.
M Covasa; J M Forbes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  48     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1994 Jun 
Date Detail:
Created Date:  1994-10-20     Completed Date:  1994-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  479-86     Citation Subset:  IM    
Department of Animal Physiology and Nutrition, University of Leeds, UK.
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MeSH Terms
Benzodiazepinones / pharmacology*
Cholecystokinin / physiology
Dose-Response Relationship, Drug
Eating / drug effects*
Food Preferences / drug effects
Injections, Intraperitoneal
Receptors, Cholecystokinin / antagonists & inhibitors*
Reg. No./Substance:
0/Benzodiazepinones; 0/Receptors, Cholecystokinin; 103420-77-5/Devazepide; 9011-97-6/Cholecystokinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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