| Effects of the CCK receptor antagonist MK-329 on food intake in broiler chickens. | |
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MedLine Citation:
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PMID: 8090818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The cholecystokinin (CCK) receptor antagonist MK-329 (previously L-364,718) was administered intraperitoneally to free-feeding broiler chickens and tested for conditioning effects using the colored food paradigm. The 8.0, 16.0, and 32.0 micrograms/kg doses of MK-329 did not exert any effect on food intake and failed to condition a color preference or aversion. When higher doses were used (90, 180, and 360 micrograms/kg) MK-329 caused a significant increase in food intake during the 2-h test period. Intravenously injected MK-329 (70, 140, and 280 micrograms/kg) produced an increase in food intake, with maximum increases occurring at a dose of 70 micrograms/kg. CCK (14 micrograms/kg) caused a reduction in feeding, and this effect was not blocked by pretreatment with intraperitoneal injection of MK-329 (32, 90, 180, and 360 micrograms/kg). The results question the role of endogenous CCK in satiety in chickens. |
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Authors:
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M Covasa; J M Forbes |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 48 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1994 Jun |
Date Detail:
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Created Date: 1994-10-20 Completed Date: 1994-10-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 479-86 Citation Subset: IM |
Affiliation:
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Department of Animal Physiology and Nutrition, University of Leeds, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzodiazepinones / pharmacology* Chickens Cholecystokinin / physiology Color Devazepide Dose-Response Relationship, Drug Eating / drug effects* Female Food Preferences / drug effects Injections, Intraperitoneal Receptors, Cholecystokinin / antagonists & inhibitors* |
| Chemical | |
Reg. No./Substance:
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0/Benzodiazepinones; 0/Receptors, Cholecystokinin; 103420-77-5/Devazepide; 9011-97-6/Cholecystokinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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