| Effects of C358A missense polymorphism of the degrading enzyme fatty acid amide hydrolase on weight loss, adipocytokines, and insulin resistance after 2 hypocaloric diets. | |
| | |
MedLine Citation:
|
PMID: 20102775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It has been demonstrated that the polymorphism 385 C/A of fatty acid amide hydrolase was associated with obesity. We decided to investigate the role of a polymorphism (cDNA 385 C->A) on insulin resistance and weight loss secondary to a low-fat vs a low-carbohydrate diet. A population of 248 patients with obesity was analyzed. Basal measurements were performed, and values were compared to those at the end of a 3-month period in which subjects received either diet I (low fat) or diet II (low carbohydrate). One hundred seventy-eight patients (71.8%) had the genotype C358C (wild-type group), and 70 (28.2%) patients had the genotype C358A (62 patients, 25%) or A358A (8 patients, 3.2%) (mutant-type group). With diet I, body mass index, weight, fat mass, waist circumference, and systolic blood pressures decreased in the wild-type and mutant-type groups. With diet II, body mass index, weight, fat mass, waist circumference, and systolic blood pressures decreased in both genotypes. With diet I, leptin, glucose, total cholesterol, triglyceride, insulin, and homeostasis model assessment for insulin sensitivity (HOMA) decreased in the wild-type group. In the mutant-type group, only cholesterol decreased in a significant way. With diet II, leptin, interleukin-6, glucose, total cholesterol, low-density lipoprotein cholesterol, insulin, HOMA, and C-reactive protein decreased in the wild-type genotype. The allele A358 of fatty acid amide hydrolase was associated with a lack of improvement on glucose insulin, HOMA, and leptin levels in both diets after weight loss. |
| | |
Authors:
|
Daniel Antonio Deluis; Manuel Gonzalez Sagrado; Rocio Aller; Olatz Izaola; Rosa Conde |
Related Documents
:
|
16162705 - Treatment of cachexia with ghrelin in patients with copd. 16786335 - Seasonal regulations of energetics, serum concentrations of leptin, and uncoupling prot... 15627725 - Effect of administration of recombinant human leptin during the neonatal period on the ... 18203145 - Seasonal adiposity, correlative changes in metabolic factors and unique reproductive ac... 7856785 - The association between leisure-time physical activity and dietary fat in american adults. 8878325 - A savant poet. |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial Date: 2010-01-27 |
Journal Detail:
|
Title: Metabolism: clinical and experimental Volume: 59 ISSN: 1532-8600 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 2010 Sep |
Date Detail:
|
Created Date: 2010-08-23 Completed Date: 2010-09-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375267 Medline TA: Metabolism Country: United States |
Other Details:
|
Languages: eng Pagination: 1387-92 Citation Subset: IM |
Copyright Information:
|
Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipokines
/
blood* Adult Amidohydrolases / genetics* Blood Glucose / genetics Calorimetry, Indirect Cytokines / blood Diet, Reducing Enzyme-Linked Immunosorbent Assay Female Genotype Humans Insulin Resistance / genetics* Male Middle Aged Obesity / blood, genetics* Polymorphism, Single Nucleotide / genetics* Statistics, Nonparametric Weight Loss / genetics* |
| Chemical | |
Reg. No./Substance:
|
0/Adipokines; 0/Blood Glucose; 0/Cytokines; EC 3.5.-/Amidohydrolases; EC 3.5.1.-/fatty-acid amide hydrolase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chronic fatigue syndrome is associated with metabolic syndrome: results from a case-control study in...
Next Document: Endothelial function in individuals with coronary artery disease with and without type 2 diabetes me...