| Effects of blood glutamate scavenging on cortical evoked potentials. | |
| | |
MedLine Citation:
|
PMID: 20607387 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It is well known that traumatic or ischemic brain injury is followed by acute excitotoxicity caused by the presence of abnormally high glutamate (Glu) in brain fluids. It has recently been demonstrated that excess Glu can be eliminated from brain into blood following the intravenous administration of oxaloacetate (OxAc), which, by scavenging blood Glu, induces an enhanced and neuroprotective brain-to-blood Glu efflux. In this study, we subjected rats to intravenous OxAc administration (i.v., 12.5, 25, and 50 mg/kg, respectively), and studied its effects on somatosensory evoked cortical potentials (EPs). Against our expectation, the amplitudes of EPs did not decrease but increased in a dose- and time-dependent manner after OxAc administration. Similar effects were observed when blood Glu scavenging was enhanced by combining OxAc (12.5 mg/kgbw) with recombinant glutamate-oxaloacetate transaminase (GOT, 0.14 nmol/100 g rat). On the basis of these results, we suggest that the changes of amplitudes of the EPs involve not only a glutamatergic but also the weakening of a GABAergic component. We cannot rule out the possibility that OxAc penetrates into the brain and improves mitochondrial functions. |
| | |
Authors:
|
Dávid Nagy; Levente Knapp; Máté Marosi; Tamás Farkas; Zsolt Kis; László Vécsei; Vivian I Teichberg; József Toldi |
Related Documents
:
|
10412027 - Cortical nadh during pharmacological manipulations of the respiratory chain and spreadi... 12182767 - Brain oxygenation and energy metabolism: part i-biological function and pathophysiology. 18321197 - Scientific justification of cryonics practice. 1460517 - Technetium-99m-hmpao cerebral perfusion scintigraphy: considerations for timely brain d... 6772297 - Blood flow and reactivity to noradrenaline in dmba-induced rat mammary neoplasia. 9742267 - Correlation of near infrared spectroscopy cerebral blood flow estimations and microsphe... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-06 |
Journal Detail:
|
Title: Cellular and molecular neurobiology Volume: 30 ISSN: 1573-6830 ISO Abbreviation: Cell. Mol. Neurobiol. Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-10-04 Completed Date: 2011-01-31 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8200709 Medline TA: Cell Mol Neurobiol Country: United States |
Other Details:
|
Languages: eng Pagination: 1101-6 Citation Subset: IM |
Affiliation:
|
Department of Physiology, Anatomy and Neuroscience, University of Szeged, Közép fasor 52, Szeged, Hungary. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Aspartate Aminotransferase, Cytoplasmic / metabolism Brain / drug effects, metabolism* Evoked Potentials, Somatosensory / drug effects, physiology* Glutamic Acid / blood* Hydrogen-Ion Concentration Male Oxaloacetate / pharmacology Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
|
0/Oxaloacetate; 56-86-0/Glutamic Acid; EC 2.6.1.-/Aspartate Aminotransferase, Cytoplasmic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Novel single nucleotide polymorphisms of the caprine PC1 gene and association with growth traits.
Next Document: Repeated stress down-regulates ?(2)- and ? (2C)-adrenergic receptors and up-regulates gene expressio...