Document Detail


The effects of BleedArrest, Celox, and TraumaDex on hemorrhage control in a porcine model.
MedLine Citation:
PMID:  20863522     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Hemorrhage is the second leading cause of death in civilian trauma and the leading cause of preventable death in military trauma. The purpose of this study was to examine the effectiveness of three hemostatic agents: BleedArrest, TraumaDex, and Celox. MATERIALS AND METHODS: This was a prospective, experimental study using male Yorkshire swine. The pigs (n = 5 per group) were randomly assigned to one of the following: BleedArrest, TraumaDex, Celox, or control. To simulate a trauma injury, the investigators generated a complex groin injury with transection of the femoral artery and vein in all pigs. After 1 min of uncontrolled hemorrhage, one of the hemostatic agents was poured into the wound, followed by standard wound packing. The control group underwent the same procedures with the exception of the hemostatic agents. In all groups, 5 min of direct manual pressure was applied to the wound followed by a standard pressure dressing. After 30 min, dressings were removed, and the amount of bleeding was determined. RESULTS: There were significant differences between the BleedArrest (mean = 21.2, SD ± 36.6 mL) TraumaDex (mean = 68, SD ± 103.5 mL) and Celox (mean = 18.l6, SD ± 41.6 mL) groups compared with Control group (mean = 230, SD ± 154 mL) (P < 0.05). However, there were no statistically significant difference between BleedArrest, TraumaDex, and Celox groups (P = 0.478). CONCLUSIONS: BleedArrest, Celox, and TraumaDex were statistically and clinically superior at controlling hemorrhage compared with the standard pressure dressing in the control group.
Authors:
Brian Gegel; James Burgert; Brian Cooley; Jacob MacGregor; Jules Myers; Sean Calder; Ralph Luellen; Michael Loughren; Don Johnson
Publication Detail:
Type:  Journal Article     Date:  2010-09-21
Journal Detail:
Title:  The Journal of surgical research     Volume:  164     ISSN:  1095-8673     ISO Abbreviation:  J. Surg. Res.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e125-9     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Affiliation:
US Army Graduate Program in Anesthesia, Brooke Army Medical Center, Fort Sam, Houston, Texas 78234-6130, USA.
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