| Effects of biphasic current pulse frequency, amplitude, duration, and interphase gap on eye movement responses to prosthetic electrical stimulation of the vestibular nerve. | |
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MedLine Citation:
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PMID: 20813652 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An implantable prosthesis that stimulates vestibular nerve branches to restore sensation of head rotation and vision-stabilizing reflexes could benefit individuals disabled by bilateral loss of vestibular (inner ear balance) function. We developed a prosthesis that partly restores normal function in animals by delivering pulse frequency modulated (PFM) biphasic current pulses via electrodes implanted in semicircular canals. Because the optimal stimulus encoding strategy is not yet known, we investigated effects of varying biphasic current pulse frequency, amplitude, duration, and interphase gap on vestibulo-ocular reflex (VOR) eye movements in chinchillas. Increasing pulse frequency increased response amplitude while maintaining a relatively constant axis of rotation. Increasing pulse amplitude (range 0- 325 μA) also increased response amplitude but spuriously shifted eye movement axis, probably due to current spread beyond the target nerve. Shorter pulse durations (range 28- 340 μs) required less charge to elicit a given response amplitude and caused less axis shift than longer durations. Varying interphase gap (range 25- 175 μs) had no significant effect. While specific values reported herein depend on microanatomy and electrode location in each case, we conclude that PFM with short duration biphasic pulses should form the foundation for further optimization of stimulus encoding strategies for vestibular prostheses intended to restore sensation of head rotation. |
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Authors:
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Natan S Davidovics; Gene Y Fridman; Bryce Chiang; Charles C Della Santina |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-09-02 |
Journal Detail:
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Title: IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society Volume: 19 ISSN: 1558-0210 ISO Abbreviation: IEEE Trans Neural Syst Rehabil Eng Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-09 Completed Date: 2011-06-02 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 101097023 Medline TA: IEEE Trans Neural Syst Rehabil Eng Country: United States |
Other Details:
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Languages: eng Pagination: 84-94 Citation Subset: IM |
Affiliation:
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Departments of Otolaryngology/Head and Neck Surgery and Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA. natan@jhu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chinchilla Electric Stimulation Therapy / methods* Eye Movements* Reflex, Vestibulo-Ocular* Vestibular Diseases / physiopathology*, rehabilitation* Vestibular Nerve / physiopathology* |
| Grant Support | |
ID/Acronym/Agency:
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1F31DC010099-01A1/DC/NIDCD NIH HHS; F31 DC010099-01A1/DC/NIDCD NIH HHS; F31 DC010099-02/DC/NIDCD NIH HHS; R01 DC009255-04/DC/NIDCD NIH HHS; R01 DC009255-05/DC/NIDCD NIH HHS; R01DC009255/DC/NIDCD NIH HHS |
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