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Effects of Benzo(a)pyrene During Pregnancy.
MedLine Citation:
PMID:  24770209     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: Preterm birth is significantly higher in African Americans. They also have higher lifelong exposure to environmental toxins like benzo(a)pyrene, which has been reported to affect fetal growth. Initial studies from our laboratory showed that rats treated with benzo(a)pyrene deliver preterm. In addition, superarray suggested that benzo(a)pyrene regulates histone deacetylases in myometrium of treated rats. Because histone deacetylases have been reported to play a role in inflammation, we measured the histone deacetylases and contractile-associated factors in myometrium of rats treated with benzo(a)pyrene in this study.
METHODS: Pregnant Long Evan rats were gavaged 150, 300, and 600 micrograms benzo(a)pyrene from day 14 to day 17 of pregnancy and euthanized after delivery. The uterus was dissected, endometrium removed, and myometrium was subjected to Western blot analysis using histone deacetylase, connexin 43, and cyclooxygenase-2 antibodies.
RESULTS: Western blot analysis performed to assess the epigenetic changes demonstrated a significant (P<.05) decrease in histone deacetylase 1, 3, and 4 but not in 2, 5, and 6 in myometrium obtained from rats treated with benzo(a)pyrene. Western analysis of inflammatory marker, cyclooxygenase-2, and contractile-associated protein connexin 43 showed a significant (P<.05) decrease in myometrium of rats treated with benzo(a)pyrene compared with the control rats.
CONCLUSIONS: Our results suggest that: 1) exposure to benzo(a)pyrene during pregnancy increases inflammatory and contractile proteins through downregulation of histone deacetylases; and 2) exposure to environmental toxins is a risk factor to preterm birth. However, additional studies are needed to assess the effects of histone deacetylase inhibitors as a therapeutic strategy to inhibit the deleterious effects of benzo(a)pyrene on pregnancy and fetal growth.
Teri-Lee Foster; Archana Laknaur; Darryl Hood; Ayman Al-Hendy; Chandrasekhar Thota
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  123 Suppl 1     ISSN:  1873-233X     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-04-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  50S     Citation Subset:  AIM; IM    
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