| Effects of Bay K 8644 and nifedipine on locomotor activity and striatal homovanillic acid concentration in acutely ethanol-treated rats. | |
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MedLine Citation:
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PMID: 1722095 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The possible involvement of voltage sensitive calcium channels (VSCCs) in both locomotor activity and striatal homovanillic acid (HVA) alterations in acutely low (0.5 g/kg) and high (2 g/kg) dose ethanol-treated rats was investigated. Both doses of ethanol produced inhibitory effects on both locomotor activity and striatal HVA levels. Bay K 8644 significantly potentiated and nifedipine reversed the locomotor inhibitory effect of low-dose ethanol, whereas both drugs did not alter locomotor activity and striatal HVA levels, when used alone. On the other hand, both Bay K 8644 and nifedipine significantly reversed the decrease in striatal HVA levels induced by the low and high doses of ethanol. |
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Authors:
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R K Tuna; L Eroğlu |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Alcohol and alcoholism (Oxford, Oxfordshire) Volume: 26 ISSN: 0735-0414 ISO Abbreviation: Alcohol Alcohol. Publication Date: 1991 |
Date Detail:
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Created Date: 1992-02-11 Completed Date: 1992-02-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8310684 Medline TA: Alcohol Alcohol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 465-71 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Istanbul Faculty of Medicine, University of Istanbul, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester
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administration & dosage,
pharmacology* Animals Drug Combinations Drug Evaluation, Preclinical Ethanol / administration & dosage, antagonists & inhibitors, pharmacology* Homovanillic Acid / analysis* Male Motor Activity / drug effects* Nifedipine / administration & dosage, pharmacology* Random Allocation Rats Rats, Inbred Strains Visual Cortex / chemistry, drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 21829-25-4/Nifedipine; 306-08-1/Homovanillic Acid; 64-17-5/Ethanol; 71145-03-4/3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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