| Effects of BUdR on developmental functions of Dictyostelium discoideum. | |
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MedLine Citation:
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PMID: 207443 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The development of Dictyostelium discoideum cells, as measured by spore yield, is somewhat more sensitive to the presence of BUdR during vegetative growth than is growth itself. Observations on the development of control and BUdR-grown cells, their protein labelling patterns and assays of 4 developmentally regulated proteins all reveal a consistent picture. BUdR appears to block spore formation by partially inhibiting several or many different earlier events during development. The relative sensitivity of development compared to growth to inhibition by the drug may be a consequence of the nature of the developmental process rather than of some unique specificity of the inhibitor. |
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Authors:
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R R Kay; J Sampson; R A Steinberg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cell differentiation Volume: 7 ISSN: 0045-6039 ISO Abbreviation: Cell Differ. Publication Date: 1978 Apr |
Date Detail:
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Created Date: 1978-08-28 Completed Date: 1978-08-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0342640 Medline TA: Cell Differ Country: IRELAND |
Other Details:
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Languages: eng Pagination: 33-45 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3',5'-Cyclic-AMP Phosphodiesterases
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metabolism Bromodeoxyuridine / pharmacology* Cell Aggregation / drug effects Dictyostelium / drug effects, physiology* Fungal Proteins / biosynthesis Myxomycetes / physiology* Spores, Fungal / drug effects, physiology UTP-Glucose-1-Phosphate Uridylyltransferase / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fungal Proteins; 59-14-3/Bromodeoxyuridine; EC 2.7.7.9/UTP-Glucose-1-Phosphate Uridylyltransferase; EC 3.1.4.17/3',5'-Cyclic-AMP Phosphodiesterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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