| Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial. | |
| | |
MedLine Citation:
|
PMID: 21115589 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate whether dietary supplementation with B vitamins or omega 3 fatty acids, or both, could prevent major cardiovascular events in patients with a history of ischaemic heart disease or stroke. DESIGN: Double blind, randomised, placebo controlled trial; factorial design. SETTING: Recruitment throughout France via a network of 417 cardiologists, neurologists, and other physicians. PARTICIPANTS: 2501 patients with a history of myocardial infarction, unstable angina, or ischaemic stroke. INTERVENTION: Daily dietary supplement containing 5-methyltetrahydrofolate (560 μg), vitamin B-6 (3 mg), and vitamin B-12 (20 μg) or placebo; and containing omega 3 fatty acids (600 mg of eicosapentanoic acid and docosahexaenoic acid at a ratio of 2:1) or placebo. Median duration of supplementation was 4.7 years. MAIN OUTCOME MEASURES: Major cardiovascular events, defined as a composite of non-fatal myocardial infarction, stroke, or death from cardiovascular disease. RESULTS: Allocation to B vitamins lowered plasma homocysteine concentrations by 19% compared with placebo, but had no significant effects on major vascular events (75 v 82 patients, hazard ratio, 0.90 (95% confidence interval 0.66 to 1.23, P=0.50)). Allocation to omega 3 fatty acids increased plasma concentrations of omega 3 fatty acids by 37% compared with placebo, but also had no significant effect on major vascular events (81 v 76 patients, hazard ratio 1.08 (0.79 to 1.47, P=0.64)). CONCLUSION: This study does not support the routine use of dietary supplements containing B vitamins or omega 3 fatty acids for prevention of cardiovascular disease in people with a history of ischaemic heart disease or ischaemic stroke, at least when supplementation is introduced after the acute phase of the initial event. TRIAL REGISTRATION: Current Controlled Trials ISRCTN41926726. |
| | |
Authors:
|
Pilar Galan; Emmanuelle Kesse-Guyot; Sébastien Czernichow; Serge Briancon; Jacques Blacher; Serge Hercberg; |
Related Documents
:
|
11192239 - Alpha-azido acids for direct use in solid-phase peptide synthesis. 8681409 - Synthesis and thromboxane a2 antagonistic activity of [[1-aryl(or benzyl)-1-(benzenesul... 1785439 - Fatty acid composition of near-term and beyond-term pig placenta. 6746609 - Purification and characterization of hyaluronic acid from the horny layer of guinea pigs. 6104669 - Leukotriene c5: a slow reacting substance derived from eicosapentaenoic acid. 7131129 - Phagocytosis of the a band following z line, and i band loss. its significance in skele... 10644239 - Basis for presentation of acid-base in two dimensions. 16927169 - Co-localization of glutamic acid decarboxylase and phosphate-activated glutaminase in n... 10083729 - A novel therapeutic trial of homogentisic aciduria in a murine model of alkaptonuria. |
Publication Detail:
|
Type: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-11-29 |
Journal Detail:
|
Title: BMJ (Clinical research ed.) Volume: 341 ISSN: 1756-1833 ISO Abbreviation: BMJ Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-11-30 Completed Date: 2010-12-13 Revised Date: 2012-03-06 |
Medline Journal Info:
|
Nlm Unique ID: 8900488 Medline TA: BMJ Country: England |
Other Details:
|
Languages: eng Pagination: c6273 Citation Subset: AIM; IM |
Affiliation:
|
UMR U557 Inserm, U1125 Inra, Cnam, Université Paris 13, CRNH IdF, F-93017 Bobigny, France. p.galan@uren.smbh.univ-paris13.fr |
| Data Bank Information | |
Bank Name/Acc. No.:
|
ISRCTN/ISRCTN41926726 |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Angina, Unstable / diet therapy Biological Markers / blood Cardiovascular Diseases / prevention & control* Dietary Supplements Double-Blind Method Fatty Acids, Omega-6 / administration & dosage*, blood Female Humans Kaplan-Meier Estimate Male Middle Aged Myocardial Infarction / diet therapy Patient Compliance Stroke / diet therapy Treatment Outcome Vitamin B Complex / administration & dosage*, blood |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Fatty Acids, Omega-6; 12001-76-2/Vitamin B Complex |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pentavalent rotavirus vaccine in developing countries: safety and health care resource utilization.
Next Document: Early magnesium modifications as a surrogate marker of efficacy of cetuximab-based anticancer treatm...