Document Detail


Effects of autonomic interventions on atrial restitution properties.
MedLine Citation:
PMID:  20561104     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The restitution hypothesis suggests that action potential duration (APD) restitution slope >1 predicts the development of alternans and fibrillation. This study aimed to investigate the effects of autonomic interventions on the restitution properties on the atria.
METHODS AND RESULTS: In 10 anesthetized open-chest dogs, multiple electrode catheters were sutured at pulmonary vein and atrial sites. The monophasic APD was recorded by an Ag-AgCl catheter. The restitution curve at each site was constructed by plotting each APD(90) against the preceding diastolic interval at incremental atrial pacing rates before and after vagal nerve stimulation (VNS) or ganglionated plexi (GP) ablation. Before GP ablation, VNS significantly shortened the APD, flattened the restitution curves and suppressed the APD alternans at each site, while increasing the atrial fibrillation (AF) inducibility and duration (P < 0.05 for all). These effects were eliminated by GP ablation. Compared with the baseline, GP ablation significantly increased the APD, steepened the restitution curves, and facilitated the APD alternans at each site while decreasing the AF inducibility and duration (P < 0.05 for all). VNS significantly increased (0.5 ± 0.2 vs 0.3 ± 0.1, P < 0.05) and GP ablation decreased (0.2 ± 0.1 vs 0.3 ± 0.1, P < 0.05) the spatial dispersion of the slopes of APDR curves, respectively.
CONCLUSIONS: The maximal slope of APDR curve alone does not fully account for the changes of AF inducibility and duration induced by autonomic interventions; instead, the spatial dispersion of the APDR kinetics may be an important determinant for susceptibility of AF.
Authors:
Zhibing Lu; Bo Cui; Bo He; Xiaorong Hu; Wei Wu; Congxin Huang; Hong Jiang
Related Documents :
20352374 - Digitalis does not improve left atrial mechanical dysfunction after successful electric...
16133854 - Electrical stimulation to identify neural elements on the heart: their role in atrial f...
24174334 - New generation drug-eluting stents for st-elevation myocardial infarction: a new paradi...
16498244 - Atrial natriuretic peptide predicts impaired atrial remodeling and occurrence of late p...
24182674 - The hero-2 ecg sub-studies in patients with st elevation myocardial infarction: implica...
15956164 - Posterior cerebral artery infarction from middle cerebral artery infarction.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  22     ISSN:  1540-8167     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-17     Completed Date:  2011-05-17     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-90     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley Periodicals, Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Fibrillation / physiopathology*
Autonomic Nervous System / physiopathology*
Dogs
Heart Atria / physiopathology*
Heart Conduction System / physiopathology*
Pulmonary Veins / physiopathology*
Vagus Nerve Stimulation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Initial experience with a multielectrode catheter equipped with the single-axis sensor technology fo...
Next Document:  Differential effect of biventricular and right ventricular DDD pacing on coronary flow reserve in pa...