Document Detail

Effects of autonomic interventions on atrial restitution properties.
MedLine Citation:
PMID:  20561104     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The restitution hypothesis suggests that action potential duration (APD) restitution slope >1 predicts the development of alternans and fibrillation. This study aimed to investigate the effects of autonomic interventions on the restitution properties on the atria.
METHODS AND RESULTS: In 10 anesthetized open-chest dogs, multiple electrode catheters were sutured at pulmonary vein and atrial sites. The monophasic APD was recorded by an Ag-AgCl catheter. The restitution curve at each site was constructed by plotting each APD(90) against the preceding diastolic interval at incremental atrial pacing rates before and after vagal nerve stimulation (VNS) or ganglionated plexi (GP) ablation. Before GP ablation, VNS significantly shortened the APD, flattened the restitution curves and suppressed the APD alternans at each site, while increasing the atrial fibrillation (AF) inducibility and duration (P < 0.05 for all). These effects were eliminated by GP ablation. Compared with the baseline, GP ablation significantly increased the APD, steepened the restitution curves, and facilitated the APD alternans at each site while decreasing the AF inducibility and duration (P < 0.05 for all). VNS significantly increased (0.5 ± 0.2 vs 0.3 ± 0.1, P < 0.05) and GP ablation decreased (0.2 ± 0.1 vs 0.3 ± 0.1, P < 0.05) the spatial dispersion of the slopes of APDR curves, respectively.
CONCLUSIONS: The maximal slope of APDR curve alone does not fully account for the changes of AF inducibility and duration induced by autonomic interventions; instead, the spatial dispersion of the APDR kinetics may be an important determinant for susceptibility of AF.
Zhibing Lu; Bo Cui; Bo He; Xiaorong Hu; Wei Wu; Congxin Huang; Hong Jiang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular electrophysiology     Volume:  22     ISSN:  1540-8167     ISO Abbreviation:  J. Cardiovasc. Electrophysiol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-17     Completed Date:  2011-05-17     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9010756     Medline TA:  J Cardiovasc Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-90     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley Periodicals, Inc.
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MeSH Terms
Atrial Fibrillation / physiopathology*
Autonomic Nervous System / physiopathology*
Heart Atria / physiopathology*
Heart Conduction System / physiopathology*
Pulmonary Veins / physiopathology*
Vagus Nerve Stimulation*

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