Document Detail


Effects of aripiprazole, risperidone, and olanzapine on 5-HT1A receptors in patients with schizophrenia.
MedLine Citation:
PMID:  23277246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the impact of various antipsychotic drugs on the 5-HT1A serotoninergic system, we performed a [F]4-(2-methoxyphenyl)-1-[2-(N-2-pirydynyl)-p-luorobenzamido]-ethyl-piperazine PET study in 19 schizophrenic patients treated with either aripiprazole, which has a partial agonist activity at 5-HT1A receptors, or second-generation antipsychotics (SGA) (olanzapine or risperidone), which do not demonstrate such property. We used a simplified reference tissue model to generate parametric images of [F]MPPF-binding potential (BPND). A significant reduction of [F]MPPF BPND was found in treated schizophrenic patients compared to age- and sex-matched healthy subjects. These modifications were mainly localized in the frontal and orbitofrontal cortex and may reflect either the pathophysiology of schizophrenia or medication effects. The schizophrenic patients treated with aripiprazole showed a reduction of global [F]MPPF BPND compared with healthy subjects and schizophrenic patients with SGA treatment. In addition, compared with matched controls, the reduction of regional [F]MPPF BPND was more marked in the schizophrenic patients treated with aripiprazole compared with those receiving SGA treatment, possibly reflecting the partial agonist of aripiprazole activity at 5-HT1A receptors.
Authors:
Jérôme Lerond; Amélie Lothe; Philippe Ryvlin; Sandrine Bouvard; Thierry d'Amato; Carolina Ciumas; Jean Daléry; Emmanuel Poulet; Mohamed Saoud
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical psychopharmacology     Volume:  33     ISSN:  1533-712X     ISO Abbreviation:  J Clin Psychopharmacol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-04     Completed Date:  2013-06-12     Revised Date:  2014-06-04    
Medline Journal Info:
Nlm Unique ID:  8109496     Medline TA:  J Clin Psychopharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  84-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Antipsychotic Agents / therapeutic use*
Benzodiazepines / metabolism,  therapeutic use*
Case-Control Studies
Cerebral Cortex / drug effects*,  metabolism,  radionuclide imaging
Drug Partial Agonism
Female
Humans
Magnetic Resonance Imaging
Male
Piperazines / diagnostic use,  metabolism,  therapeutic use*
Positron-Emission Tomography
Pyridines / diagnostic use
Quinolones / metabolism,  therapeutic use*
Radiopharmaceuticals / diagnostic use
Receptor, Serotonin, 5-HT1A / drug effects*,  metabolism
Risperidone / metabolism,  therapeutic use*
Schizophrenia / diagnosis,  drug therapy*,  metabolism,  radionuclide imaging
Schizophrenic Psychology
Treatment Outcome
Young Adult
Chemical
Reg. No./Substance:
0/4-(2'-methoxyphenyl)-1-(2'-(N-2'-pyridinyl)-p-(18F)fluorobenzamido )ethylpiperazine; 0/Antipsychotic Agents; 0/Piperazines; 0/Pyridines; 0/Quinolones; 0/Radiopharmaceuticals; 112692-38-3/Receptor, Serotonin, 5-HT1A; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 82VFR53I78/aripiprazole; L6UH7ZF8HC/Risperidone
Comments/Corrections
Comment In:
J Clin Psychopharmacol. 2014 Jun;34(3):396-7   [PMID:  24717255 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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