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Effects Of Antihypertensive And Triglyceride Lowering Agents On Splenocyte Apoptosis In Rats With Fatty Liver.
MedLine Citation:
PMID:  23489555     Owner:  NLM     Status:  Publisher    
Individuals with the metabolic syndrome (MS) and non-alcoholic fatty liver disease (NFALD) have an increased incidence of infection and infection-related mortality. Rats given fructose-enriched diet (FED) develop the MS including NAFLD. In this study, we characterized changes in splenocyte apoptosis in FED rats given medications to treat various components of the MS. Apoptosis of splenocytes may induce immunosuppression. Splenocyte apoptosis was evaluated by activated caspase-3 immunohistochemistry in the periarterial sheath (PALS), (a T-cell area), follicles (B-cell area), marginal (B-cell area) and in the red pulp zones. FED administration caused an enormous increase in splenocyte apoptosis in all of the spleen zones: PALS (+2966%), follicles (+3025%), marginal (+5228%) and red pulp (+7000%). Administration of captopril to the FED rats was associated with a further increase in the splenocyte apoptosis only in the marginal (150%), PALS (+105%) and red pulp (+67%) zones. Bezafibrate administration to the FED rats was associated with no further increase in apoptosis rates. Amlodipine administration to the FED rats was associated with almost complete amelioration of the splenoctye apoptosis that was induced by the FED diet. These pharmacological manipulations were also associated with changes in the hepatic lipids composition and oxidative milieu that did not correlate to the changes in splenocyte apoptosis. NAFLD in FED rats is associated with an increase in splenic apoptosis. Agents administered to treat components of the MS in FED rats may lead to divergent changes in the splenic histology and splenocyte apoptosis.
Zvi Ackerman; Maria Grozovski; Mor Oron-Herman; Talma Rosenthal; Ben-Ami Sela; Gail Amir
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-14
Journal Detail:
Title:  Basic & clinical pharmacology & toxicology     Volume:  -     ISSN:  1742-7843     ISO Abbreviation:  Basic Clin. Pharmacol. Toxicol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101208422     Medline TA:  Basic Clin Pharmacol Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors Basic & Clinical Pharmacology & Toxicology © 2013 Nordic Pharmacological Society.
Departments of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
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