Document Detail

Effects of Antihypertensive Drugs on Specific Harmonic Indices of the Pulse Waveform in Normotensive Wistar Kyoto Rats.
MedLine Citation:
PMID:  22007621     Owner:  NLM     Status:  Publisher    
We used a self-comparison method and harmonic analysis to compare the blood pressure wave before and after the injection of antihypertensive drugs (atenolol, captopril, and losartan) in normotensive Wistar Kyoto rats. Systolic and diastolic blood pressures decreased significantly after the intraperitoneal injection of drugs. Atenolol significantly reduced all the harmonic proportions of the pulse wave, while captopril and losartan significantly increased the first and fourth harmonic proportions. These findings are the same as those reported for human subjects and confirm that harmonic analysis of the pressure pulse is a useful method to study the efficacy of antihypertensive drugs.
Sheng Hung Wang; Ming Yie Jan; Wei Kung Wang; Yuh Ying Lin Wang
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-18
Journal Detail:
Title:  Clinical and experimental hypertension (New York, N.Y. : 1993)     Volume:  -     ISSN:  1525-6006     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305929     Medline TA:  Clin Exp Hypertens     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Electrical Engineering, National Taiwan University , Taipei , Taiwan.
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