| Effects of Antihypertensive Drugs on Specific Harmonic Indices of the Pulse Waveform in Normotensive Wistar Kyoto Rats. | |
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MedLine Citation:
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PMID: 22007621 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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We used a self-comparison method and harmonic analysis to compare the blood pressure wave before and after the injection of antihypertensive drugs (atenolol, captopril, and losartan) in normotensive Wistar Kyoto rats. Systolic and diastolic blood pressures decreased significantly after the intraperitoneal injection of drugs. Atenolol significantly reduced all the harmonic proportions of the pulse wave, while captopril and losartan significantly increased the first and fourth harmonic proportions. These findings are the same as those reported for human subjects and confirm that harmonic analysis of the pressure pulse is a useful method to study the efficacy of antihypertensive drugs. |
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Authors:
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Sheng Hung Wang; Ming Yie Jan; Wei Kung Wang; Yuh Ying Lin Wang |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-18 |
Journal Detail:
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Title: Clinical and experimental hypertension (New York, N.Y. : 1993) Volume: - ISSN: 1525-6006 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9305929 Medline TA: Clin Exp Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Electrical Engineering, National Taiwan University , Taipei , Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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