| Effects of anemia and uremia and a combination of both on cardiovascular structures. | |
| | |
MedLine Citation:
|
PMID: 20628260 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Cardiovascular complications are a major cause of morbidity and mortality in chronic renal failure (CRF) patients. Chronic anemia is a complication of CRF and a cardiovascular risk factor per se. It was the aim of the present study to clarify whether uremia and anemia are additive or supra-additive with respect to cardiovascular alterations. METHODS: Thirty SD rats were sham operated (sham) or subtotally nephrectomized (SNX). Both groups were subdivided into anemic (target hemoglobin 10 g/dl, by tail artery punctures) and untreated animals. Blood pressure, echocardiographic measurements and morphometric investigations were performed. The study was terminated after 16 weeks. RESULTS: Heart rate and blood pressure were similar in all groups. Anemia was comparable in sham+anemia and SNX+anemia. Left ventricular end-diastolic pressure was significantly higher in untreated SNX and SNX+anemia than in sham. Anemia and SNX caused comparable left ventricular hypertrophy (LVH), which was significantly higher in SNX+anemia. In sham animals, anemia induced thickening of intramyocardial arteries, which was significantly more pronounced in SNX with no additional effect of anemia. CONCLUSIONS: Experimentally, anemia and CRF induced LVH and intramyocardial arteriolar thickening. If both are combined, the increase in LVH is even more marked, whereas there are no additional effects on intramyocardial structural alterations. |
| | |
Authors:
|
J S Jürgensen; R Grimm; K Benz; S Philipp; K U Eckardt; K Amann |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-13 |
Journal Detail:
|
Title: Kidney & blood pressure research Volume: 33 ISSN: 1423-0143 ISO Abbreviation: Kidney Blood Press. Res. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-08-24 Completed Date: 2010-12-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9610505 Medline TA: Kidney Blood Press Res Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 274-81 Citation Subset: IM |
Copyright Information:
|
Copyright (c) 2010 S. Karger AG, Basel. |
Affiliation:
|
Department of Pathology, University of Erlangen-Nürnberg, Erlangen, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anemia
/
complications* Animals Arterioles / pathology Blood Pressure Capillaries / pathology Disease Models, Animal Heart Rate Hypertrophy, Left Ventricular / etiology*, pathology, ultrasonography Kidney Failure, Chronic / complications* Male Nephrectomy Rats Rats, Sprague-Dawley Uremia / complications* Vascular Diseases / etiology*, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Tissue factor is induced by resistin in human coronary artery endothelial cells by the NF-?B-depende...
Next Document: Prehypertensive African-American women have preserved nitric oxide and renal function but high cardi...