Document Detail

Effects of alfacalcidol on back extensor strength gained through back extensor exercise in postmenopausal women with osteoporosis.
MedLine Citation:
PMID:  23044701     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of this study was to investigate the additive effect of the active form of vitamin D3 on the gain in back extensor strength through a back extensor exercise.
DESIGN: A total of 107 postmenopausal women with osteoporosis were randomly divided into two groups: the D3 group and the control group. Both groups were treated with calcium and alendronate and undertook the back extensor exercise. Alfacalcidol was prescribed only to the D3 group.
RESULTS: There was no significant difference in the demographic data between the two groups. Ninety-four participants who completed a 4-mo intervention were subjected to per-protocol analysis. There was no significant difference in the improvement in back extensor strength between two the groups (P = 0.349). All subjects were further categorized into two subgroups by age. In the older subgroup (≥68 yrs), no significant difference was found in the improvement in back extensor strength (P = 0.316). In the younger subgroup (<68 yrs), the back extensor strength in the D3 group was significantly more improved than in the control group (P = 0.034).
CONCLUSIONS: The results of this study suggest that the administration of the active form of vitamin D3 enhances the beneficial effects of the back extensor exercise in patients younger than those in their late 60s.
Seigo Hara; Koshi N Kishimoto; Hiroshi Okuno; Masahiko Tanaka; Hideo Saito; Akira Oizumi; Eiji Itoi
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of physical medicine & rehabilitation / Association of Academic Physiatrists     Volume:  92     ISSN:  1537-7385     ISO Abbreviation:  Am J Phys Med Rehabil     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-18     Completed Date:  2013-03-12     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  8803677     Medline TA:  Am J Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  101-10     Citation Subset:  AIM; IM    
Department of Orthopaedic Surgery, Kurihara Central Hospital, Kurihara, Japan.
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MeSH Terms
Age Factors
Bone Density Conservation Agents / therapeutic use*
Cholecalciferol / therapeutic use
Collagen Type I / urine
Exercise / physiology*
Hydroxycholecalciferols / therapeutic use*
Middle Aged
Movement / physiology
Muscle Strength / physiology*
Osteoporosis, Postmenopausal / drug therapy*,  physiopathology
Peptides / urine
Prospective Studies
Quality of Life
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Collagen Type I; 0/Hydroxycholecalciferols; 0/Peptides; 0/collagen type I trimeric cross-linked peptide; 67-97-0/Cholecalciferol; URQ2517572/alfacalcidol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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