| Effects of Aging, TNF-α and Exercise Training On Angiotensin II-Induced Vasoconstriction of Rat Skeletal Muscle Arterioles. | |
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MedLine Citation:
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PMID: 22923503 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Skeletal muscle vascular resistance during physical exertion is higher with old age. The purpose of this study was to determine whether, 1) aging enhances angiotensin II (ANG II)-induced vasoconstriction, 2) the pro-inflammatory cytokine tumor necrosis factor alpha (TNF-α) contributes to alterations in ANG II-mediated vasoconstriction with aging, 3) exercise training attenuates putative age-associated increases in ANG II-mediated vasoconstriction, and 4) the mechanism(s) through which aging and exercise training alter ANG II-induced vasoconstriction in skeletal muscle arterioles. Male Fischer 344 rats were assigned to 4 groups: young sedentary (YS; 4 months), old sedentary (OS; 24 months), young trained (YT) and old trained (OT). In a separate group of YS and OS animals, a TNF type 1 receptor (TNF-R1) inhibitor was administered subcutaneously for 10 wk. First-order arterioles were isolated from soleus and gastrocnemius muscles for in vitro experimentation. Old age augmented ANG II-induced vasoconstriction in both soleus (young: 27 ± 3%; old: 38 ± 4%) and gastrocnemius (young: 42 ± 6%; old: 64 ± 9%) muscle arterioles; this augmented vasoconstriction was abolished with the removal of the endothelium, NPPGPP-nitro-L-arginine methyl ester (L-NAME), and chronic inhibition of TNF-α. In addition, exercise training ameliorated the age-induced increase in ANG II-vasoconstriction. These findings demonstrate that old age enhances and exercise training diminishes ANG II-induced vasoconstrictor responses in skeletal muscle arterioles through an endothelium-dependent NOS signaling pathway. In addition, the enhancement of ANG II vasoconstriction with old age appears to be related to a proinflammatory state. |
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Authors:
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Yoonjung Park; Rhonda D Prisby; Bradley Jon Behnke; James Michael Dominguez; Lisa A Lesniewski; Anthony John Donato; Judy M Muller-Delp; Micheal D Delp |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-23 |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: - ISSN: 1522-1601 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Texas Tech University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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