Document Detail


Effects of aerobic training on oxidative status in postsurgical non-small cell lung cancer patients: a pilot study.
MedLine Citation:
PMID:  20863590     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Oxidative stress is postulated to contribute to the initiation, promotion, and progression of non-small cell lung cancer (NSCLC). We investigated the effects of supervised, moderate-intensity aerobic training on urinary markers of oxidative status in patients with postsurgical NSCLC.
PATIENTS AND METHODS: Sixteen patients with histologically confirmed stage I-IIIB NSCLC were recruited. Exercise training consisted of aerobic cycle ergometry sessions at 60 to ≥70% of baseline peak workload 20-45 min·d(-1), 3 d·wk(-1)for 14 weeks. Oxidative status was assessed via four urinary F(2)-isoprostanes isomers: iPF (2-alpha)-III, 2,3-dinor-iPF(2 alpha)-III, iPF (2-alpha)-VI, and 8,12-iso-iPF(2 alpha)-VI using liquid chromatography with tandem mass spectrometry detection. Peak oxygen consumption (VO2peak) was assessed using a maximal, incremental, cardiopulmonary exercise test with expired gas analysis.
RESULTS: A composite index of all four F2-isoprostanes isomers increased from baseline to post-intervention by 32% (p = 0.08). Concerning individual isomers, iPF (2-alpha)-III increased by 0.09 (+55%; p = .010), iPF (2-alpha)-VI by 0.81 (+29%; p = 0.04), and 8,12-iso-iPF(2 alpha)-VI by 0.59 (+28%; p = 0.07) from baseline to postintervention. There was no change in 2,3-dinor-iPF(2 alpha)-III levels. VO2peak increased 1.1 mL·kg·(-1) min(-1) (p = 0.14) and peak workload increased 10 Watts (p < .001). Change in VO2peak was not associated with change in markers of oxidative status.
CONCLUSIONS: Aerobic training was associated with significant increases in urinary measures of oxidative status in postsurgical NSCLC. The clinical implications of these findings are currently unknown. Further studies are required to elucidate the complex relationship between aerobic training, oxidative stress, tumor biology, and response to cytotoxic agents in mouse and human models of cancer.
Authors:
Lee W Jones; Neil D Eves; Ivan Spasojevic; Frances Wang; Dora Il'yasova
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-09-21
Journal Detail:
Title:  Lung cancer (Amsterdam, Netherlands)     Volume:  72     ISSN:  1872-8332     ISO Abbreviation:  Lung Cancer     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-07     Completed Date:  2011-08-16     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  8800805     Medline TA:  Lung Cancer     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  45-51     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Duke University Medical Center, Durham, North Carolina 27710, USA. lee.w.jones@duke.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Carcinoma, Non-Small-Cell Lung / metabolism*,  surgery
Exercise*
F2-Isoprostanes / urine
Female
Humans
Lung Neoplasms / metabolism*,  surgery
Male
Middle Aged
Oxidative Stress / physiology
Oxygen Consumption*
Pilot Projects
Postoperative Period
Grant Support
ID/Acronym/Agency:
CA125458/CA/NCI NIH HHS; CA133895/CA/NCI NIH HHS; CA138634/CA/NCI NIH HHS; CA142566/CA/NCI NIH HHS; CA143254/CA/NCI NIH HHS; R01 CA138624/CA/NCI NIH HHS; R01 CA142566/CA/NCI NIH HHS; R21 CA125458/CA/NCI NIH HHS; R21 CA133895/CA/NCI NIH HHS; R21 CA143254/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/F2-Isoprostanes
Comments/Corrections

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