| Effects of aerobic training on airway inflammation in asthmatic patients. | |
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MedLine Citation:
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PMID: 20581719 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: : There is evidence suggesting that physical activity has anti-inflammatory effects in many chronic diseases; however, the role of exercise in airway inflammation in asthma is poorly understood. We aimed to evaluate the effects of an aerobic training program on eosinophil inflammation (primary aim) and nitric oxide (secondary aim) in patients with moderate or severe persistent asthma. METHODS: : Sixty-eight patients randomly assigned to either control (CG) or aerobic training (TG) groups were studied during the period between medical consultations. Patients in the CG (educational program + breathing exercises; N = 34) and TG (educational program + breathing exercises + aerobic training; N = 34) were examined twice a week during a 3-month period. Before and after the intervention, patients underwent induced sputum, fractional exhaled nitric oxide (FeNO), pulmonary function, and cardiopulmonary exercise testing. Asthma symptom-free days were quantified monthly, and asthma exacerbation was monitored during 3 months of intervention. RESULTS: : At 3 months, decreases in the total and eosinophil cell counts in induced sputum (P = 0.004) and in the levels of FeNO (P = 0.009) were observed after intervention only in the TG. The number of asthma symptom-free days and V˙O2max also significantly improved (P < 0.001), and lower asthma exacerbation occurred in the TG (P < 0.01). In addition, the TG presented a strong positive relationship between baseline FeNO and eosinophil counts as well as their improvement after training (r = 0.77 and r = 0.9, respectively). CONCLUSIONS: : Aerobic training reduces sputum eosinophil and FeNO in patients with moderate or severe asthma, and these benefits were more significant in subjects with higher levels of inflammation. These results suggest that aerobic training might be useful as an adjuvant therapy in asthmatic patients under optimized medical treatment. |
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Authors:
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Felipe Augusto Rodrigues Mendes; Francine Maria Almeida; Alberto Cukier; Rafael Stelmach; Wilson Jacob-Filho; Milton A Martins; Celso Ricardo Fernandes Carvalho |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medicine and science in sports and exercise Volume: 43 ISSN: 1530-0315 ISO Abbreviation: Med Sci Sports Exerc Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: United States |
Other Details:
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Languages: eng Pagination: 197-203 Citation Subset: IM; S |
Affiliation:
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1Department of Physical Therapy, School of Medicine, University of São Paulo, São Paulo, BRAZIL; 2Department of Medicine, School of Medicine, University of São Paulo, São Paulo, BRAZIL; 3Pulmonary Department, School of Medicine, University of São Paulo, São Paulo, BRAZIL; and 4Department of Geriatrics, School of Medicine, University of São Paulo, São Paulo, BRAZIL. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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