| The Effects of Aerobic Training and Age on Plasma sICAM-1. | |
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MedLine Citation:
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PMID: 22972240 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Chronic low-grade systemic inflammation plays a role in the development of cardiovascular (CV) disease. Habitual endurance exercise training reduces the risk of CV disease in part through anti-inflammatory mechanisms. The purpose of this study was to investigate the effects of age, endurance training status, and their interaction on pro-inflammatory plasma cytokines involved in the pathogenesis of CV disease. Subjects were BMI-matched young (25±3 years; endurance trained: n=9, sedentary: n=11) and older (62±5 years; endurance-trained: n=12, sedentary: n=11) men. Plasma cytokine concentrations were determined by multiplex cytometric bead assay. Soluble intercellular adhesion molecule-1 (sICAM-1) levels were 40% higher in sedentary older men compared to young sedentary subjects (P=0.048), but they were not different between the young and older trained men. Furthermore, sICAM-1 levels were negatively correlated with maximal oxygen uptake (V˙O2max; r= - 0.38, P=0.01) across all subjects. There were no significant differences among the groups in plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), soluble tumor necrosis-α receptor (sTNFR), soluble CD40 ligand (sCD40L), or resistin. We conclude that habitual endurance training is associated with an attenuated age-related increase in plasma sICAM-1. |
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Authors:
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G M Many; N T Jenkins; S Witkowski; J M Damsker; J Hagberg |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-9-12 |
Journal Detail:
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Title: International journal of sports medicine Volume: - ISSN: 1439-3964 ISO Abbreviation: Int J Sports Med Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-9-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008349 Medline TA: Int J Sports Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Children's National Medical Center, Research Center for Genetic Medicine, Washington DC, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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