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Effects of Aerobic Exercise Training on C1q Tumor Necrosis Factor α-Related Protein Isoform 5 (Myonectin): Association with Insulin Resistance and Mitochondrial DNA Density in Women.
MedLine Citation:
PMID:  22031510     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Context:The C1q TNFα-related protein (C1QTNF) families exhibit a C-terminal complement factor C1q globular domain similar to that of TNF. However, their clinical implications are largely unknown. We recently found that the C1q TNFα-related protein isoform 5 (C1QTNF5 or myonectin) level was increased in insulin-resistant rodents and mitochondrial DNA (mtDNA)-depleted myocytes.Objective:We aimed to determine the effects of aerobic exercise training on C1QTNF5 level and its association with insulin resistance and mtDNA density in young and old healthy women.Design and Setting:Fourteen healthy young women aged 22.5 ± 2.7 yr and 14 healthy older women aged 60.3 ± 5.2 yr performed aerobic exercise at 60-80% of maximal oxygen consumption (VO(2)max) over three 1-h sessions per week for 10 wk. Insulin resistance was assessed by homeostasis model assessment of insulin resistance and adiponectin concentration. Serum C1QTNF5 level was estimated by immunoblotting. The mtDNA/28S rRNA ratio was used to determine mtDNA density.Results:VO(2)max increased significantly after the exercise training from 33.1 ± 6.2 to 35.3 ± 5.3 ml/kg · min in younger women and from 23.2 ± 3.1 to 27.2 ± 4.8 ml/kg · min in older women (P < 0.05). The C1QTNF5 level and homeostasis model assessment of insulin resistance decreased significantly after exercise training and were correlated positively (r = 0.462; P < 0.01). There were negative correlations between the changes in C1QTNF5 level and the changes in VO(2)max, mtDNA density, and adiponectin level (r = -0.495, -0.672, and -0.569, respectively; all P < 0.01).Conclusion:These findings suggest a physiological function for C1QTNF5 (myonectin) in linking insulin resistance with quantitative changes in mtDNA. Further research exploring the role of C1QTNF5 in the development of insulin resistance is warranted.
Authors:
Soo Lim; Sung Hee Choi; Bo Kyung Koo; Seon Mee Kang; Ji Won Yoon; Hak Chul Jang; Soon Mi Choi; Man Gyoon Lee; Wan Lee; Hayley Shin; Young-Bum Kim; Hong Kyu Lee; Kyong Soo Park
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-26
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  -     ISSN:  1945-7197     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Internal Medicine (S.L., S.H.C., S.M.K., J.W.Y., H.C.J.), Seoul National University Bundang Hospital, Seongnam, Korea 463-707; Department of Internal Medicine (B.K.K.), Boramae Medical Center, Seoul, Korea 156-707; Department of Internal Medicine (S.L., S.H.C., S.M.K., J.W.Y., H.C.J., H.K.L., K.S.P.), Seoul National University College of Medicine, Seoul, Korea 110-744; Graduate School of Physical Education (S.M.C., M.G.L.), Kyung Hee University, Yongin, Korea 446-701; Department of Biochemistry (W.L.), Dongguk University College of Medicine, Kyungju, Korea 780-714; Johns Hopkins Bloomberg School of Public Health (H.S.), Baltimore, Maryland 21205; Division of Endocrinology (Y.B.K.), Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215.
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