| Effects of Aerobic Exercise on Premenopausal Sex Hormone Levels: Results of the WISER Study, A Randomized Clinical Trial in Healthy, Sedentary, Eumenorrheic Women. | |
| | |
MedLine Citation:
|
PMID: 21467231 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background. It is hypothesized that exercise can lead to a decrease in breast cancer risk through several hormonal and non-hormonal mechanisms. The Women in Steady Exercise Research (WISER) study investigated the effects of aerobic exercise on premenopausal sex hormone levels.Methods. 391 sedentary, healthy, young eumenorrheic women were randomized into an exercise intervention of 30 minutes of aerobic exercise 5 times a week for approximately 16 weeks (n=212), or into a control group (n=179). Serum levels of estradiol, estrone sulfate, testosterone, and sex hormone binding globulin (SHBG), all in the midfollicular phase, and of progesterone, in the midluteal phase, were measured at baseline and at the end of the 16-week period. Results. Compared to the controls (n=153), exercisers (n=166) experienced significant increases in aerobic fitness, lean body mass, and decreases in percent body fat. There were no significant changes in body weight and menstrual cycle length between or within groups. Progesterone decreased significantly in exercisers; however, this reduction was similar to that of the control group. No significant changes between or within groups were found for any of the other sex hormones or SHBG.Conclusions. In premenopausal women, 16 weeks of 150 minutes per week of moderate aerobic exercise in young women did not significantly alter sex hormone or SHBG levels. Impact. Any favorable effects that moderate aerobic exercise without an associated weight change may have on breast cancer risk in premenopausal women are unlikely to be a consequence of changes in levels of sex hormones or SHBG. |
| | |
Authors:
|
Alma J Smith; William R Phipps; Andrea Y Arikawa; Maureen O'Dougherty; Beth Kaufman; William Thomas; Kathryn H Schmitz; Mindy Kurzer |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-5 |
Journal Detail:
|
Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: - ISSN: 1538-7755 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-6 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1Food Science and Nutrition, University of Minnesota. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Metabolites of a Tobacco-Specific Lung Carcinogen in Children Exposed to Secondhand or Thirdhand Tob...
Next Document: Novel changes in glycosylation of serum Apo-J in patients with hepatocellular carcinoma.