Document Detail

Effects of Adding Butyric Acid to PN on Gut-Associated Lymphoid Tissue and Mucosal Immunoglobulin A Levels.
MedLine Citation:
PMID:  21467244     Owner:  NLM     Status:  Publisher    
BACKGROUND: Parenteral nutrition (PN) causes intestinal mucosal atrophy, gut-associated lymphoid tissue (GALT) atrophy and dysfunction, leading to impaired mucosal immunity and increased susceptibility to infectious complications. Therefore, new PN formulations are needed to maintain mucosal immunity. Short-chain fatty acids have been demonstrated to exert beneficial effects on the intestinal mucosa. We examined the effects of adding butyric acid to PN on GALT lymphocyte numbers, phenotypes, mucosal immunoglobulin A (IgA) levels, and intestinal morphology in mice. METHODS: Male Institute of Cancer Research mice (n = 103) were randomized to receive either standard PN (S-PN), butyric acid-supplemented PN (Bu-PN), or ad libitum chow (control) groups. The mice were fed these respective diets for 5 days. In experiment 1, cells were isolated from Peyer's patches (PPs) to determine lymphocyte numbers and phenotypes (αβTCR(+), γδTCR(+), CD4(+), CD8(+), B220(+) cells). IgA levels in small intestinal washings were also measured. In experiment 2, IgA levels in respiratory tract (bronchoalveolar and nasal) washings were measured. In experiment 3, small intestinal morphology was evaluated. RESULTS: Lymphocyte yields from PPs and small intestinal, bronchoalveolar, and nasal washing IgA levels were all significantly lower in the S-PN group than in the control group. Bu-PN moderately, but significantly, restored PP lymphocyte numbers, as well as intestinal and bronchoalveolar IgA levels, as compared with S-PN. Villous height and crypt depth in the small intestine were significantly decreased in the S-PN group vs the control group, however Bu-PN restored intestinal morphology. CONCLUSIONS: A new PN formula containing butyric acid is feasible and would ameliorate PN-induced impairment of mucosal immunity. (JPEN J Parenter Enteral Nutr. XXXX;xx:xx-xx).
Satoshi Murakoshi; Kazuhiko Fukatsu; Jiro Omata; Tomoyuki Moriya; Midori Noguchi; Daizoh Saitoh; Isamu Koyama
Related Documents :
8383674 - Structural requirements for the binding of modified proteins to the scavenger receptor ...
3171394 - Regulation of the metabolism of lipid emulsion model lipoproteins by a saturated acyl c...
18547084 - Competition between lipases and monoglycerides at interfaces.
14602084 - Free radical release in c6 glial cells enriched in hexacosanoic acid: implication for x...
6128194 - Cytochrome p-450-dependent covalent binding of 1,1,2,2-tetrachloroethane in vitro.
6547774 - Formation of specific amino acid sequences during carbodiimide-mediated condensation of...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-5
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  -     ISSN:  0148-6071     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
National Defense Medical College Research Institute.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Home care clients in the last year of life: is material deprivation associated with service characte...
Next Document:  The acceptability of 'Trauma Risk Management' within the UK Armed Forces.