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Effects of Acute Intracranial Hypertension on Extracerebral Organs: A Randomized Experimental Study in Pigs.
MedLine Citation:
PMID:  22899228     Owner:  NLM     Status:  Publisher    
Background The study was conducted to determine the effects of isolated acute intracranial hypertension (AICH) on extracerebral organs.Design A total of 14 mechanically ventilated pigs were randomized to two groups of seven each: (1) control and (2) AICH.Methods AICH was induced by inflating an intracranial balloon catheter. The inflation volume was adjusted to keep intracranial pressure between 30 and 40 cm H2O. Hemodynamics, gas-exchange, and global oxygen delivery parameters were observed over a 4-hour period. At the end of the 4-hour period, tissue samples of heart, lungs, liver, and kidneys were collected and histologically graded for inflammation, edema, and cell damage (necrosis) using semiquantitative scores.Results Animals with AICH had increased heart rate and cardiac output, and higher scores for inflammation, edema, and necrosis in heart, lung, kidney, and liver tissues (all p < 0.05). Peripheral and mixed-venous oxygen saturations were unaffected.Conclusions Isolated AICH induces injury to multiple extracerebral organs, even in the absence of hypoperfusion or hypoxemia.
Jan Florian Heuer; Maren Selke; Thomas A Crozier; Paolo Pelosi; Peter Herrmann; Christina Perske; Michael Quintel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-16
Journal Detail:
Title:  Journal of neurological surgery. Part A, Central European neurosurgery     Volume:  -     ISSN:  2193-6323     ISO Abbreviation:  J Neurol Surg A Cent Eur Neurosurg     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101580767     Medline TA:  J Neurol Surg A Cent Eur Neurosurg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Department of Anaesthesiology, Emergency and Intensive Care Medicine, University Hospital Göttingen, Göttingen, Germany.
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