Document Detail


The effects of acupuncture on the brain networks for emotion and cognition: an observation of gender differences.
MedLine Citation:
PMID:  20851113     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acupuncture modulates brain activity at the limbic-paralimbic-neocortical network (LPNN) and the default mode network (DMN). Since these brain networks show gender differences when mediating emotional and cognitive tasks, we thus hypothesize that women and men may also respond differently to acupuncture procedure at these brain regions. In order to test this hypothesis, we retrieved the data of 38 subjects, 19 females and 19 males, who had brain fMRI during acupuncture from previous studies and reanalyzed them based on sex status. Deactivation at the LPNN/DMN during needle manipulation of acupuncture was more extensive in females than in males, particularly in the posterior cingulate (BA31), precuneus (BA7m) and angular gyrus (BA39). The functional correlations between the right BA31 and pregenual cingulate (BA32), hippocampus or contralateral BA31 were significantly stronger in females than in males. The angular gyrus (BA39) was functionally correlated with BA31 in females; in contrast, it was anticorrelated with BA31 in males. Soreness, a major component of the psychophysical responses to needle manipulation, deqi, was correlated in intensity with deactivation of the angular gyrus in females; no such relationships were observed in males. In contrast to lesser deactivation at the LPNN/DMN networks, needle manipulation during acupuncture induced greater activation at the secondary somatosensory cortex and stronger functional connectivity with the anterior-middle cingulate (BA32/24) in males than in females. Our study suggests that brains with sex dimorphism may process the acupuncture stimulation differently between women and men.
Authors:
Wei Qiao Qiu; Joshua Claunch; Jian Kong; Erika E Nixon; Jiliang Fang; Ming Li; Mark Vangel; Kathleen Kin-Sang Hui
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2010-09-17
Journal Detail:
Title:  Brain research     Volume:  1362     ISSN:  1872-6240     ISO Abbreviation:  Brain Res.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-08     Completed Date:  2011-09-23     Revised Date:  2013-10-22    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  56-67     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Psychiatry, Tufts Medical Center, Tufts University School of Medicine, USA. wqiu67@bu.edu
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MeSH Terms
Descriptor/Qualifier:
Acupuncture / methods*
Adult
Brain / physiology*
Cognition / physiology*
Emotions / physiology*
Female
Humans
Male
Nerve Net / physiology*
Sex Characteristics*
Grant Support
ID/Acronym/Agency:
1-P01-002048-01//PHS HHS; K01 AT003883/AT/NCCAM NIH HHS; K23 AG022476/AG/NIA NIH HHS; K23AG-022476/AG/NIA NIH HHS; NS 34189./NS/NINDS NIH HHS; P41RR14075/RR/NCRR NIH HHS; R21AT004497/AT/NCCAM NIH HHS; R21AT00978/AT/NCCAM NIH HHS
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