| The effects of acarbose treatment on intimal hyperplasia in a rat carotid endarterectomy model of diet-induced insulin resistance. | |
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MedLine Citation:
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PMID: 20675317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Increased carotid restenosis due to revascularization therapy is associated with insulin resistance. We hypothesize that glucose control using acarbose may attenuate intimal hyperplasia in rat carotid endarterectomy model of diet-induced insulin resistance. METHODS: Rats were fed low-fat complex carbohydrate (control) or high-fat sucrose (insulin resistance) for 4 months. Three days preoperatively, some high-fat-sucrose rats were on acarbose, remainder of the rats received placebo. Rat carotids were assessed with duplex pre-and postoperatively. Acarbose and placebo continued for 2 weeks. Glucose, insulin, blood flow velocities and intimal hyperplasia were determined. RESULTS: High-fat sucrose plus acarbose attenuated intimal hyperplasia. Post-drug high-fat sucrose glucose decreased. Blood flow velocities postoperatively elevated above baseline. High-fat sucrose increased blood flow velocities postoperatively, which was attenuated with acarbose. CONCLUSION: Glucose control by acarbose in rat carotid endarterectomy model of diet-induced insulin resistance resulted in attenuation of intimal hyperplasia. |
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Authors:
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John O Nyalala; Shaoke Luo; Danielle N Campbell; Aliza T Brown; Mohammed M Moursi |
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Publication Detail:
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Type: Journal Article Date: 2010-07-30 |
Journal Detail:
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Title: Vascular and endovascular surgery Volume: 44 ISSN: 1938-9116 ISO Abbreviation: Vasc Endovascular Surg Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-15 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136421 Medline TA: Vasc Endovascular Surg Country: United States |
Other Details:
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Languages: eng Pagination: 560-7 Citation Subset: IM |
Affiliation:
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Department of Surgery, Division of Vascular Surgery, University of Arkansas for Medical Sciences, Little Rock, AR, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acarbose
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pharmacology* Animals Blood Flow Velocity Blood Glucose / drug effects, metabolism Carotid Arteries / drug effects*, pathology, physiopathology, surgery Carotid Stenosis / etiology, pathology, physiopathology, prevention & control* Dietary Sucrose / administration & dosage Disease Models, Animal Endarterectomy, Carotid / adverse effects* Hyperplasia Hypoglycemic Agents / pharmacology* Insulin / blood Insulin Resistance* Male Rats Rats, Sprague-Dawley Regional Blood Flow Time Factors Tunica Intima / drug effects*, pathology, surgery Ultrasonography, Doppler, Pulsed |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Dietary Sucrose; 0/Hypoglycemic Agents; 11061-68-0/Insulin; 56180-94-0/Acarbose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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