Document Detail

Effects of AP5 infusion into the lateral ventricle on the activities and hippocampal electrical patterns of sleep episodes in rats.
MedLine Citation:
PMID:  16376955     Owner:  NLM     Status:  MEDLINE    
Although N-methyl-D-aspartate (NMDA) receptors of the hippocampus are mainly associated with learning and memory that might occur "on-line" during sharp waves (SPWs) and theta-rhythm, the participation of hippocampal NMDA receptors in sleep-related processes has not been well studied. In this study, the activity of sleep episodes, hippocampal SPWs and theta-rhythm were recorded in rats received a repeated infusion of NMDA receptor antagonist, D,L-2-amino-5-phosphonopentanoic acid (AP5), into the lateral ventricle in a 5-h daytime sleep. The first trial AP5 infusion (30 mM/2 microl) did not change measures of the activity of slow wave sleep (SWS), paradoxical sleep (PS) and awake episodes, but induced a delay in the latency of the first onset of PS; in the hippocampal EEG, it increased the amplitude of SPWs within SWS and shifted the amplitude/spectral power of theta-rhythm from high to low frequency within PS. The repeated AP5 infusion augmented the activity of SWS, and impaired PS and awake episodes; in the EEG-sleep picture, it maintained high scores of SPWs with the complete blockade of theta-rhythm generation. When AP5 rat was woken, the theta-rhythm was seen during exploratory behavior. These findings provide evidence that hippocampal NMDA receptors via SPWs or directly associated with the synaptic events of theta-rhythm generation are critical for the PS activities.
Enver Melik; Emine Babar; Mustafa Guven
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-27
Journal Detail:
Title:  Physiology & behavior     Volume:  87     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-06     Completed Date:  2006-04-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  377-82     Citation Subset:  IM    
Cukurova University, Medical Faculty, Division of Neurophysiology, Department of Physiology, 01330 Balcali, Adana/Turkey.
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MeSH Terms
2-Amino-5-phosphonovalerate / administration & dosage,  pharmacology*
Electroencephalography / drug effects*
Excitatory Amino Acid Antagonists / administration & dosage,  pharmacology*
Hippocampus / drug effects,  physiology*
Injections, Intraventricular
Rats, Wistar
Sleep / drug effects*
Sleep, REM / drug effects
Theta Rhythm
Wakefulness / physiology
Reg. No./Substance:
0/Excitatory Amino Acid Antagonists; 76726-92-6/2-Amino-5-phosphonovalerate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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