Document Detail

Effects of ACTH on brain midline structures in infants with infantile spasms.
MedLine Citation:
PMID:  8534277     Owner:  NLM     Status:  MEDLINE    
Changes of the midline structures of the brain, including the pons, cerebellar vermis, and corpus callosum, induced by adrenocorticotropic hormone (ACTH) therapy in 7 infants with infantile spasms were investigated using magnetic resonance imaging. Decreased volume of these parts of the brain was induced in almost all infants. Decreased volume of the pons was thought to be closely related to sleep disturbance during ACTH therapy. These results may demonstrate that the cessation of convulsive episodes in infants with infantile spasms treated with ACTH is due to its direct action on the brainstem.
Y Konishi; K Hayakawa; M Kuriyama; M Saito; Y Fujii; M Sudo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric neurology     Volume:  13     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-02-06     Completed Date:  1996-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  134-6     Citation Subset:  IM    
Department of Pediatrics, Fukui Medical School, Japan.
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MeSH Terms
Adrenocorticotropic Hormone / adverse effects*,  therapeutic use
Anticonvulsants / adverse effects*,  therapeutic use
Brain / drug effects*,  pathology
Cerebellum / drug effects,  pathology
Corpus Callosum / drug effects,  pathology
Dose-Response Relationship, Drug
Drug Administration Schedule
Magnetic Resonance Imaging*
Pons / drug effects,  pathology
Reference Values
Spasms, Infantile / drug therapy*
Reg. No./Substance:
0/Anticonvulsants; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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