| Effects of ABCB1 polymorphisms on plasma carbamazepine concentrations and pharmacoresistance in Chinese patients with epilepsy. | |
| | |
MedLine Citation:
|
PMID: 21493161 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
P-glycoprotein may play a role in drug resistance in epilepsy by limiting gastrointestinal absorption and brain access of antiepileptic drugs (AEDs). We sought to investigate the effects of ABCB1 polymorphisms on plasma carbamazepine (CBZ) concentrations and pharmacoresistance in Chinese patients with epilepsy. C1236T, G2677T/A, and C3435T polymorphisms of ABCB1 were genotyped by polymerase chain reaction amplification followed by restriction fragment length polymorphism analysis or direct automated DNA sequencing in 84 patients treated with CBZ monotherapy. Patients with 3435-TT (n=15) had lower adjusted CBZ concentrations than those with 3435-CC (n=30) (P=0.026). However there were no associations between all the studied genotypes, haplotypes, or diplotypes involving ABCB1 C1236T, G2677T/A, and C3435T polymorphisms and pharmacoresistance in the patient cohort. Our results suggest that ABCB1 3435-TT is associated with decreased plasma CBZ levels in Chinese patients with epilepsy. However, whether this contributes to CBZ resistance needs to be further investigated in a larger cohort of patients. |
| | |
Authors:
|
Hongmei Meng; Guimei Guo; Jinyan Ren; Hui Zhou; Yubin Ge; Yingjie Guo |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-4-12 |
Journal Detail:
|
Title: Epilepsy & behavior : E&B Volume: - ISSN: 1525-5069 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
|
Created Date: 2011-4-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100892858 Medline TA: Epilepsy Behav Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
The First Hospital of Jilin University, Changchun, People's Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Activation of human invariant natural killer T cells with a thioglycoside analogue of ?-galactosylce...
Next Document: Nursing Home Admission in Elderly Subjects with Dementia: Predictive Factors and Future Challenges.