Document Detail

Effects of an 8-week weight-loss program on cardiovascular disease risk factors and regional body composition.
MedLine Citation:
PMID:  12173568     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the influence of weight loss on multiple cardiovascular disease (CVD) risk factors. DESIGN: Overweight women (n = 12; mean 44.2% fat) and men (n = 10; mean 30.7% fat) participated in an 8 week weight-loss program that included dietary, exercise, multi-vitamin/mineral supplementation, and behavior modification components. Measurement of total and regional body composition assessed using dual energy X-ray absorptiometry (DEXA), circumferences and blood sampling for total cholesterol, LDL cholesterol, HDL cholesterol, triacylglycerols, homocysteine, insulin and leptin were performed before and after the weight loss intervention. RESULTS: Subjects increased their physical activity and decreased their energy intake, resulting in a mean decrease in body mass of - 4.3 +/- 3.4 kg in women and -4.7 +/- 3.1 kg in men. Fat accounted for 88 and 58% of the decrease in body mass in men and women, respectively. Proportionally, men lost significantly more fat mass from the trunk region compared to women. Serum total and LDL cholesterol were significantly decreased in men (-11 and -14%, respectively) but not women (-3 and -3%, respectively) and there were no changes in HDL cholesterol and triacylglycerols. Serum leptin was significantly decreased (-36%) and highly correlated to fat mass (r= 0.839). There were no changes in serum insulin and plasma homocysteine. CONCLUSIONS: These data indicate that short-term weight loss resulting from reducing percentage energy from fat, increasing physical activity and vitamin/mineral supplements including folic acid has a favorable effect on regional body composition and total and LDL cholesterol with minimal effects on HDL cholesterol, triacylglycerols, homocysteine and insulin and the effects are greater in men compared to women. Supplementation with folic acid or emphasis on folic acid-rich foods may be an important component of a weight loss program to prevent increases in homocysteine.
J S Volek; A L Gómez; D M Love; A M Weyers; R Hesslink; J A Wise; W J Kraemer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  56     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-08-09     Completed Date:  2002-10-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  585-92     Citation Subset:  IM    
The Human Performance Laboratory, The University of Connecticut, Storrs 06269-1110, USA.
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MeSH Terms
Absorptiometry, Photon
Body Composition / physiology*
Body Constitution
Cardiovascular Diseases / blood,  etiology*
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Dietary Supplements
Energy Intake
Folic Acid / administration & dosage,  metabolism
Homocysteine / blood*
Insulin / blood
Leptin / blood
Lipids / blood
Obesity / blood,  therapy*
Risk Factors
Sex Factors
Weight Loss / physiology*
Reg. No./Substance:
0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Leptin; 0/Lipids; 11061-68-0/Insulin; 454-28-4/Homocysteine; 59-30-3/Folic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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