| Effects of 8-chloroadenosine-3',5'-monophosphate in combination with irradiation in L5178Y mouse lymphoblasts. | |
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MedLine Citation:
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PMID: 7946447 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of a new anticancer drug, 8-chloroadenosine 3',5'-monophosphate (8-Cl-cAMP-), a site selective cAMP analog, that inhibits growth of cancer cells in vitro, was examined in L5178Y (LY) murine lymphoma cells. Two LY sublines were used, grown in full Fisher's medium: LY-R, radiation resistant and LY-S, radiation sensitive. The latter was also adapted to grow in simplified medium. In the full medium conversion of 8-Cl-cAMP to 8-chloroadenosine presumably was the case of cytotoxicity. In the simplified medium this conversion was limited and the cytotoxic effect much less pronounced. Cytotoxicity was equal in LY-R and LY-S cells and it was not related to changes in the cell cycle distribution; the latter were observed in LY-S, but not in LY-R cells. There was no interaction of the drug with x-rays in LY cells grown either in full or simplified medium. |
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Authors:
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I Buraczewska; I Szumiel; S Zagórski; G G Afanasjev |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta oncologica (Stockholm, Sweden) Volume: 33 ISSN: 0284-186X ISO Abbreviation: Acta Oncol Publication Date: 1994 |
Date Detail:
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Created Date: 1994-12-21 Completed Date: 1994-12-21 Revised Date: 2009-05-12 |
Medline Journal Info:
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Nlm Unique ID: 8709065 Medline TA: Acta Oncol Country: NORWAY |
Other Details:
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Languages: eng Pagination: 671-5 Citation Subset: IM |
Affiliation:
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Department of Radiobiology and Health Protection, Institute of Nuclear Chemistry and Technology, Warsaw, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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8-Bromo Cyclic Adenosine Monophosphate
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analogs & derivatives*,
therapeutic use Animals Antineoplastic Agents / therapeutic use* Cell Cycle / drug effects, radiation effects Cell Division / drug effects, radiation effects Cell Survival / drug effects, radiation effects Combined Modality Therapy Drug Screening Assays, Antitumor Immunologic Factors / therapeutic use* Lymphoma / drug therapy*, pathology, radiotherapy* Mice Tumor Cells, Cultured |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Immunologic Factors; 23583-48-4/8-Bromo Cyclic Adenosine Monophosphate; 41941-56-4/8-chloro-cyclic adenosine monophosphate |
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