Document Detail

Effects of 8-OH-DPAT, buspirone and ICS 205-930 on feeding in a novel environment: comparisons with chlordiazepoxide and FG 7142.
MedLine Citation:
PMID:  2147516     Owner:  NLM     Status:  MEDLINE    
Previously, the 5-hydroxytryptamine (5-HT)1A receptor agonists, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and buspirone and the 5-HT3 receptor antagonist ICS 205-930 have been shown to exert anxiolytic-like effects in several animal models. In the experiments reported here the effects of these compounds on feeding behaviour and food preference in a novel environment were examined, and compared with the effects of the anxiolytic drug chlordiazepoxide and the anxiogenic compound FG 7142. Chlordiazepoxide significantly reduced the latency to begin eating and prolonged the total time spent eating; chlordiazepoxide also abolished food neophobia, by significantly increasing the time spent eating novel food items. In contrast, FG 7142 significantly increased eating latency and reduced eating duration. Both 8-OH-DPAT and buspirone significantly enhanced eating duration, but unlike chlordiazepoxide eating was directed only towards the familiar food. In addition buspirone, but not 8-OH-DPAT, reduced eating latency. ICS 205-930 significantly increased eating latency and reduced eating duration; however, these effects were observed only at the lowest dose tested. All of these behavioural effects were observed only when animals were unfamiliar with the testing situation, and cannot be accounted for in terms of changes in mechanisms controlling hunger. The behavioural paradigm used in these experiments may induce a competition between the drives to explore a novel environment and to eat. It is suggested that the tendency of buspirone and 8-OH-DPAT to suppress exploratory activity may thus result in enhanced feeding duration.(ABSTRACT TRUNCATED AT 250 WORDS)
P J Fletcher; M Davies
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychopharmacology     Volume:  102     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1990  
Date Detail:
Created Date:  1991-01-17     Completed Date:  1991-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  301-8     Citation Subset:  IM    
Neuropsychiatric Research Division, University of Saskatchewan, Saskatoon, Canada.
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MeSH Terms
Appetite Depressants / pharmacology*
Buspirone / pharmacology*
Carbolines / pharmacology*
Chlordiazepoxide / pharmacology*
Feeding Behavior / drug effects
Food Deprivation
Indoles / pharmacology*
Rats, Inbred Strains
Serotonin Antagonists / pharmacology*
Tetrahydronaphthalenes / pharmacology*
Reg. No./Substance:
0/Appetite Depressants; 0/Carbolines; 0/Indoles; 0/Serotonin Antagonists; 0/Tetrahydronaphthalenes; 36505-84-7/Buspirone; 58-25-3/Chlordiazepoxide; 78538-74-6/FG 7142; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin; 89565-68-4/tropisetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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