| Effects of 8-2 fluorotelomer alcohol on oleic acid formation in the liver of rats. | |
| | |
MedLine Citation:
|
PMID: 16880635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Effects of 8-2 fluorotelomer alcohol on fatty acid composition of lipid in the liver of rats were investigated. Feeding of male rats with a diet that contained 8-2 fluorotelomer alcohol at concentrations of 0.2, 0.4 and 0.8% (w/w) for 14 d caused a significant increase in proportion and content of oleic acid (18 : 1 (n-9)) in the liver. The treatment of rats with 8-2 fluorotelomer alcohol increased activities of palmitoyl-CoA chain elongase (PCE) and stearoyl-CoA desaturase (SCD) and mRNA expressions for rat fatty acid elongase 2 (rELO2) and stearoyl-CoA desaturase 1 (SCD1), but neither rat fatty acid elongase 1 (rELO1) or stearoyl-CoA desaturase 2 (SCD2), in the liver in dose-dependent manners. Multiple regression analyses, which were performed to estimate relative contribution of PCE and SCD for determination of the proportion or the content of 18 : 1 (n-9), revealed that the three parameters were significantly correlated and that standardized partial regression coefficient of PCE was higher than that of SCD. These results suggest that 8-2 fluorotelomer alcohol caused considerable changes in the composition and the content of fatty acid, especially 18 : 1 (n-9), in the liver by inducing PCE and SCD, and that PCE plays a crucial role in the increased proportion of 18 : 1 (n-9) in the liver of the rats given fluorotelomer alcohol. |
| | |
Authors:
|
Yuko Iwase; Naomi Kudo; Tomoaki Toyama; Masafumi Tamura; Atsushi Mitsumoto; Yoichi Kawashima |
Related Documents
:
|
21447075 - The effects of corrosive substances on human bone, teeth, hair, nails, and soft tissue* 14637195 - Glycyrrhetinic acid-induced permeability transition in rat liver mitochondria. 6539235 - Triacylglycerol secretion and fatty acid synthesis by the liver in acute uremic rats. 7263665 - Demonstration of the occurrence of inactive fatty acid synthetase in rat liver by immun... 3604265 - Reactions of theophylline, theobromine and caffeine with fenton's reagent--simulation o... 22449985 - Neochloris oleoabundans grown in enriched natural seawater for biodiesel feedstock: eva... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Biological & pharmaceutical bulletin Volume: 29 ISSN: 0918-6158 ISO Abbreviation: Biol. Pharm. Bull. Publication Date: 2006 Aug |
Date Detail:
|
Created Date: 2006-08-01 Completed Date: 2006-10-18 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 9311984 Medline TA: Biol Pharm Bull Country: Japan |
Other Details:
|
Languages: eng Pagination: 1740-6 Citation Subset: IM |
Affiliation:
|
Faculty of Pharmaceutical Sciences, Josai University, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Base Sequence DNA Primers Fatty Alcohols / pharmacology* Liver / drug effects*, enzymology, metabolism Male Oleic Acid / biosynthesis* Polymerase Chain Reaction RNA, Messenger / genetics Rats Rats, Wistar Stearoyl-CoA Desaturase / genetics |
| Chemical | |
Reg. No./Substance:
|
0/1,1,2,2-tetrahydroheptadecafluorodecanol-3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol; 0/DNA Primers; 0/Fatty Alcohols; 0/RNA, Messenger; 112-80-1/Oleic Acid; EC 1.14.19.1/Stearoyl-CoA Desaturase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix me...
Next Document: Conditioned medium from feeder STO cells increases the attachment of mouse embryonic stem cells.