Document Detail

Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity, and amphetamine anorexia in the rat.
MedLine Citation:
PMID:  282297     Owner:  NLM     Status:  MEDLINE    
Bilateral 6-hydroxydopamine lesions of the nucleus accumbens septi (NAS) and olfactory tubercle (OT) caused enhanced intake of wet mash in 23-hr-food-deprived rats tested in photocell activity cages during restricted 30-min sessions. This mild hyperphagia was accompanied by a significant hypoactivity in the group with NAS/OT lesions. No hyperphagia was observed during a prolonged 120-min test session or in free-feeding tests conducted in the home cage. Anorexia induced by d-amphetamine (.5 and 1.5 mg/kg) was unaltered by the lesion, although the locomotor stimulant action of the drug was attenuated. A second experiment showed that the NAS/OT lesion also enhanced food intake in the photocell cages during 30-min sessions with dry food pellets but that food-associated drinking was concomitantly reduced. The results are consistent with the hypothesis that the behavioral changes caused by mesolimbic neuron destruction result in part from an inability to switch from one behavioral activity to another.
G F Koob; S J Riley; S C Smith; T W Robbins
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of comparative and physiological psychology     Volume:  92     ISSN:  0021-9940     ISO Abbreviation:  J Comp Physiol Psychol     Publication Date:  1978 Oct 
Date Detail:
Created Date:  1979-03-24     Completed Date:  1979-03-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0414612     Medline TA:  J Comp Physiol Psychol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  917-27     Citation Subset:  IM    
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MeSH Terms
Anorexia / chemically induced*
Attention / physiology
Central Nervous System / physiology*
Dextroamphetamine / pharmacology*
Dopamine / physiology
Drinking Behavior / physiology
Eating Disorders / chemically induced*
Feeding Behavior / physiology*
Hydroxydopamines / pharmacology*
Motor Activity / physiology*
Nucleus Accumbens / drug effects,  physiology*
Olfactory Pathways / drug effects,  physiology*
Septal Nuclei / physiology*
Reg. No./Substance:
0/Hydroxydopamines; 51-64-9/Dextroamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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