| Effects of 5HTTLPR on cardiovascular response to an emotional stressor. | |
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MedLine Citation:
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PMID: 21364197 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To replicate a prior main effect of the serotonin transporter gene promoter (5HTTLPR) genotype on cardiovascular reactivity (CVR) and explore caregiver stress as a potential moderator of 5HTTLPR effects on CVR. On the basis of prior findings, we hypothesized that the more transcriptionally active allele variants would be associated with increased CVR. METHODS: Expression of the serotonin transporter is affected by the genotype of the 5HTTLPR (S-short and L-long forms) as well as the genotype of the SNP rs25531 within this region. Based on the combined genotypes for these polymorphisms, we designated each allele as a Hi or Lo expressing allele according to expression levels-resulting in HiHi, HiLo, and LoLo groups. We examined the relationship between 5HTTLPR genotype and CVR in 164 caregivers and 158 noncaregivers. Main effects of 5HTTLPR on baseline adjusted blood pressure (systolic and diastolic blood pressures) and heart rate (HR) reactivity were examined, along with moderation by caregiving. RESULTS: The 5HTTLPR × Caregiver Stress interaction moderated both systolic blood pressure (p < .02) and HR (p < .02) reactivity. In controls, the Hi activity allelic variants were associated with greater systolic blood pressure and HR reactivity as compared with the Lo activity variants. In caregivers, 5HTTLPR genotype was not associated with CVR. CONCLUSIONS: Replication in this study's control group of our prior finding that 5HTTLPR alleles associated with Hi activity are associated with increased CVR to an emotion recall stressor strengthens the case that this association is real and could be partially responsible for the increased cardiovascular disease observed in persons carrying the 5HTTLPR L allele. |
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Authors:
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Beverly H Brummett; Ilene C Siegler; Allison Ashley-Koch; Redford B Williams |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-03-01 |
Journal Detail:
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Title: Psychosomatic medicine Volume: 73 ISSN: 1534-7796 ISO Abbreviation: Psychosom Med Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-09 Completed Date: 2012-03-15 Revised Date: 2013-04-11 |
Medline Journal Info:
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Nlm Unique ID: 0376505 Medline TA: Psychosom Med Country: United States |
Other Details:
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Languages: eng Pagination: 318-22 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Behavioral Medicine, Duke University Medical Center, Box 2969, Durham, NC 27710, USA. brummett@acpub.duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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African Americans Alleles Blood Pressure / genetics*, physiology Cardiovascular Diseases / epidemiology, genetics, psychology Caregivers / psychology* Emotions European Continental Ancestry Group Female Gene Frequency Genetic Predisposition to Disease Genotype Heart Rate / genetics*, physiology Humans Linear Models Male Middle Aged Polymorphism, Single Nucleotide / genetics Promoter Regions, Genetic / genetics Risk Factors Serotonin Plasma Membrane Transport Proteins / genetics*, metabolism Socioeconomic Factors Stress, Psychological / epidemiology, genetics*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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5P01 HL036587/HL/NHLBI NIH HHS; M01RR30/RR/NCRR NIH HHS; P01 HL036587/HL/NHLBI NIH HHS; P01 HL036587-21/HL/NHLBI NIH HHS; R01AG19605/AG/NIA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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