Document Detail


Effects of 5HTTLPR on cardiovascular response to an emotional stressor.
MedLine Citation:
PMID:  21364197     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To replicate a prior main effect of the serotonin transporter gene promoter (5HTTLPR) genotype on cardiovascular reactivity (CVR) and explore caregiver stress as a potential moderator of 5HTTLPR effects on CVR. On the basis of prior findings, we hypothesized that the more transcriptionally active allele variants would be associated with increased CVR.
METHODS: Expression of the serotonin transporter is affected by the genotype of the 5HTTLPR (S-short and L-long forms) as well as the genotype of the SNP rs25531 within this region. Based on the combined genotypes for these polymorphisms, we designated each allele as a Hi or Lo expressing allele according to expression levels-resulting in HiHi, HiLo, and LoLo groups. We examined the relationship between 5HTTLPR genotype and CVR in 164 caregivers and 158 noncaregivers. Main effects of 5HTTLPR on baseline adjusted blood pressure (systolic and diastolic blood pressures) and heart rate (HR) reactivity were examined, along with moderation by caregiving.
RESULTS: The 5HTTLPR × Caregiver Stress interaction moderated both systolic blood pressure (p < .02) and HR (p < .02) reactivity. In controls, the Hi activity allelic variants were associated with greater systolic blood pressure and HR reactivity as compared with the Lo activity variants. In caregivers, 5HTTLPR genotype was not associated with CVR.
CONCLUSIONS: Replication in this study's control group of our prior finding that 5HTTLPR alleles associated with Hi activity are associated with increased CVR to an emotion recall stressor strengthens the case that this association is real and could be partially responsible for the increased cardiovascular disease observed in persons carrying the 5HTTLPR L allele.
Authors:
Beverly H Brummett; Ilene C Siegler; Allison Ashley-Koch; Redford B Williams
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-03-01
Journal Detail:
Title:  Psychosomatic medicine     Volume:  73     ISSN:  1534-7796     ISO Abbreviation:  Psychosom Med     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-09     Completed Date:  2012-03-15     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  318-22     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Behavioral Medicine, Duke University Medical Center, Box 2969, Durham, NC 27710, USA. brummett@acpub.duke.edu
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MeSH Terms
Descriptor/Qualifier:
African Americans
Alleles
Blood Pressure / genetics*,  physiology
Cardiovascular Diseases / epidemiology,  genetics,  psychology
Caregivers / psychology*
Emotions
European Continental Ancestry Group
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Heart Rate / genetics*,  physiology
Humans
Linear Models
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics
Promoter Regions, Genetic / genetics
Risk Factors
Serotonin Plasma Membrane Transport Proteins / genetics*,  metabolism
Socioeconomic Factors
Stress, Psychological / epidemiology,  genetics*,  metabolism
Grant Support
ID/Acronym/Agency:
5P01 HL036587/HL/NHLBI NIH HHS; M01RR30/RR/NCRR NIH HHS; P01 HL036587/HL/NHLBI NIH HHS; P01 HL036587-21/HL/NHLBI NIH HHS; R01AG19605/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins
Comments/Corrections

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