Document Detail


Effects of the 5HT(1A) agonist anxiolytic gepirone on benzodiazepine withdrawal signs in rats.
MedLine Citation:
PMID:  11224088     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The effects of gepirone at 3, 9 and 27mg/kg (b.i.d.) on benzodiazepine (BZ) withdrawal signs were studied in rats pretreated with chlordiazepoxide for 21 days at doses up to 40mg/kg b.i.d. The BZ withdrawal indices studied were weight loss and anorexia. At 9 and 27, but not 3mg/kg (b.i.d.) gepirone potentiated the weight loss and anorexia seen during BZ withdrawal. These effects could not be attributed simply to high dose drug-induced "malaise" inhibiting food intake, since in drug-naive animals gepirone stimulated food intake and increased bodyweight. These data show clearly that gepirone potentiates BZ withdrawal signs. Similar findings have been reported recently in studies with ipsapirone (Goudie and Leathley, 1991). Such effects could be mediated by the a(2)-adrenoceptor antagonist actions of 1-(2-pyrimidinyl)piperazine (1-PP), an active metabolite of both gepirone and ipsapirone. Such findings may explain why prior BZ experience impairs the clinical response to buspirone-type anxiolytics acting at the 5-HT(1A) receptor.
Authors:
A.J. Goudie; M.J. Leathley
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Behavioural pharmacology     Volume:  2     ISSN:  1473-5849     ISO Abbreviation:  Behav Pharmacol     Publication Date:  1991 Dec 
Date Detail:
Created Date:  2001-Feb-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9013016     Medline TA:  Behav Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  461-469     Citation Subset:  -    
Affiliation:
Psychopharmacology Research Unit, Psychology Department, Liverpool University, P.O. Box 147, Liverpool, L69 3BX, UK.
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