| Effects of 5 years of hormonal replacement therapy on menopausal symptoms and blood pressure-a randomised controlled study. | |
MedLine Citation:
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PMID: 14559383 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To study the effects of hormonal replacement on hot flushes, other symptoms linked to menopause, and blood pressure. METHODS: The study included 1006 early postmenopausal women aged 45-58 years, participating in the Danish Osteoporosis Prevention Study (DOPS) randomised to Hormonal replacement therapy (HRT) (n=502) or no HRT (n=504) in an open label trial. Symptom scores were recorded at baseline, after 6 month, 1, 2, and 5 years on a modified Greene scale (range 0-4 with 0 equalling no symptoms, and 4 maximal symptoms). RESULTS: HRT efficiently alleviated hot flushes (mean+/-S.E.M. score 0.48+/-0.04 in HRT vs. 0.83+/-0.05 in no HRT after 5 years, P<0.01 by repeated measures ANOVA), sleeping difficulties associated with hot flushes (0.21+/-0.60 vs. 0.37+/-0.86, P<0.01), vaginal dryness (0.45+/-0.04 vs. 0.73+/-0.05, P<0.01), dyspareunia (0.27+/-0.04 vs. 0.39+/-0.04, P<0.01), and libido (0.48+/-0.05 vs. 0.59+/-0.05, P=0.08). In the untreated group the occurrence of mood swings (from 0.77+/-0.05 at baseline to 0.45+/-0.04 after 5 years, 2P<0.01) and oedemas (from 0.59+/-0.04 to 0.43+/-0.04, 2P=0.02) decreased with age while the occurrence of incontinence increased (from 0.43+/-0.03 to 0.52+/-0.04, 2P<0.01). These changes were not influenced by HRT. Furthermore, HRT had no influence on presence of headache (0.54+/-0.05 vs. 0.58+/-0.05 after 5 years), voiding pattern (0.49+/-0.04 vs. 0.53+/-0.04), or blood pressure (mean systolic pressure 123+/-18 vs. 123+/-19, diastolic pressure 77+/-10 vs. 77+/-11). CONCLUSIONS: HRT is efficient in controlling hot flushes and vaginal dryness, and symptoms related to these conditions. However, no effect on blood pressure or other menopause symptoms was recorded. |
Authors:
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Peter Vestergaard; Anne Pernille Hermann; Lis Stilgren; Charlotte Landbo Tofteng; Ole Helmer Sørensen; Pia Eiken; Stig Pors Nielsen; Leif Mosekilde |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial |
Journal Detail:
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Title: Maturitas Volume: 46 ISSN: 0378-5122 ISO Abbreviation: Maturitas Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-10-15 Completed Date: 2004-03-08 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7807333 Medline TA: Maturitas Country: Ireland |
Other Details:
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Languages: eng Pagination: 123-32 Citation Subset: IM |
Affiliation:
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Department of Endocrinology and Metabolism C, The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK-8000 C Aarhus, Denmark. p-vest@post4.tele.dk |
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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drug effects* Cohort Studies Denmark Dyspareunia / drug therapy Edema / drug therapy Estrogen Replacement Therapy* / adverse effects Estrogens / administration & dosage, therapeutic use Fecal Incontinence / drug therapy Female Follow-Up Studies Headache / drug therapy Hot Flashes / drug therapy* Humans Middle Aged Patient Compliance Postmenopause* / drug effects Progestins / administration & dosage, therapeutic use Sleep Disorders / drug therapy Vaginal Diseases / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Estrogens; 0/Progestins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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