Document Detail

Effects of 5 years of hormonal replacement therapy on menopausal symptoms and blood pressure-a randomised controlled study.
MedLine Citation:
PMID:  14559383     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To study the effects of hormonal replacement on hot flushes, other symptoms linked to menopause, and blood pressure. METHODS: The study included 1006 early postmenopausal women aged 45-58 years, participating in the Danish Osteoporosis Prevention Study (DOPS) randomised to Hormonal replacement therapy (HRT) (n=502) or no HRT (n=504) in an open label trial. Symptom scores were recorded at baseline, after 6 month, 1, 2, and 5 years on a modified Greene scale (range 0-4 with 0 equalling no symptoms, and 4 maximal symptoms). RESULTS: HRT efficiently alleviated hot flushes (mean+/-S.E.M. score 0.48+/-0.04 in HRT vs. 0.83+/-0.05 in no HRT after 5 years, P<0.01 by repeated measures ANOVA), sleeping difficulties associated with hot flushes (0.21+/-0.60 vs. 0.37+/-0.86, P<0.01), vaginal dryness (0.45+/-0.04 vs. 0.73+/-0.05, P<0.01), dyspareunia (0.27+/-0.04 vs. 0.39+/-0.04, P<0.01), and libido (0.48+/-0.05 vs. 0.59+/-0.05, P=0.08). In the untreated group the occurrence of mood swings (from 0.77+/-0.05 at baseline to 0.45+/-0.04 after 5 years, 2P<0.01) and oedemas (from 0.59+/-0.04 to 0.43+/-0.04, 2P=0.02) decreased with age while the occurrence of incontinence increased (from 0.43+/-0.03 to 0.52+/-0.04, 2P<0.01). These changes were not influenced by HRT. Furthermore, HRT had no influence on presence of headache (0.54+/-0.05 vs. 0.58+/-0.05 after 5 years), voiding pattern (0.49+/-0.04 vs. 0.53+/-0.04), or blood pressure (mean systolic pressure 123+/-18 vs. 123+/-19, diastolic pressure 77+/-10 vs. 77+/-11). CONCLUSIONS: HRT is efficient in controlling hot flushes and vaginal dryness, and symptoms related to these conditions. However, no effect on blood pressure or other menopause symptoms was recorded.
Peter Vestergaard; Anne Pernille Hermann; Lis Stilgren; Charlotte Landbo Tofteng; Ole Helmer Sørensen; Pia Eiken; Stig Pors Nielsen; Leif Mosekilde
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Maturitas     Volume:  46     ISSN:  0378-5122     ISO Abbreviation:  Maturitas     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-15     Completed Date:  2004-03-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7807333     Medline TA:  Maturitas     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  123-32     Citation Subset:  IM    
Department of Endocrinology and Metabolism C, The Osteoporosis Clinic, Aarhus Amtssygehus, Aarhus University Hospital, Tage Hansens Gade 2, DK-8000 C Aarhus, Denmark.
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MeSH Terms
Blood Pressure / drug effects*
Cohort Studies
Dyspareunia / drug therapy
Edema / drug therapy
Estrogen Replacement Therapy* / adverse effects
Estrogens / administration & dosage,  therapeutic use
Fecal Incontinence / drug therapy
Follow-Up Studies
Headache / drug therapy
Hot Flashes / drug therapy*
Middle Aged
Patient Compliance
Postmenopause* / drug effects
Progestins / administration & dosage,  therapeutic use
Sleep Disorders / drug therapy
Vaginal Diseases / drug therapy
Reg. No./Substance:
0/Estrogens; 0/Progestins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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