| Effects of 5-fluorouracil derivative UFT on thymidylate synthetase and thymidine kinase in rat colorectal tumors. | |
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MedLine Citation:
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PMID: 10226549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Thymidylate synthetase and thymidine kinase are key enzymes involved in de novo and salvage pathways for pyrimidine nucleotide synthesis, respectively. MATERIALS AND METHODS: Weekly injections of 1,2-dimethyl-hydrazine induced high incidence of colorectal adenocarcinomas in rats. RESULTS: An increased activity of thymidylate synthetase was found in the poorly differentiated adenocarcinomas of the chemically induced rat colorectal tumors. Six-week oral administration of 1-(2-tetrahydrofuryl)-5-fluorouracil in combination with uracil (UFT) reduced the total number of colorectal tumors, with the reduction of thymidylate synthetase activity in the poorly-differentiated type, though the mRNA expression of thymidylate synthetase and thymidine kinase differed little between the groups with or without UFT treatment. CONCLUSIONS: These results indicate that the long-term oral administration using UFT suppresses colorectal carcinogenesis and the growth of the poorly-differentiated type tumors. |
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Authors:
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S Sakamoto; Y Kawachi; T Iwama; K Kuwa; T Suzuki; T Mitamura; H Kudo; S Sassa; S Yoshimura; T Maemura; T Nakayama; M Ohsawa; Y Hara |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 19 ISSN: 0250-7005 ISO Abbreviation: Anticancer Res. Publication Date: 1999 Jan-Feb |
Date Detail:
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Created Date: 1999-05-20 Completed Date: 1999-05-20 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: GREECE |
Other Details:
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Languages: eng Pagination: 245-50 Citation Subset: IM |
Affiliation:
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Department of Surgery, School of Medicine, Tokyo Medical and Dental University, Japan. motoend@mri.tmd.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / therapeutic use* Colorectal Neoplasms / drug therapy*, enzymology, pathology Drug Combinations Male RNA, Messenger / analysis Rats Tegafur / pharmacology* Thymidine Kinase / genetics, metabolism* Thymidylate Synthase / genetics, metabolism* Uracil / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Drug Combinations; 0/RNA, Messenger; 0/UFT(R) drug; 17902-23-7/Tegafur; 66-22-8/Uracil; EC 2.1.1.45/Thymidylate Synthase; EC 2.7.1.21/Thymidine Kinase |
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