Document Detail

Effects of 4 weeks treatment with chlorpromazine and/or trihexyphenidyl on the pituitary-gonadal axis in male paranoid schizophrenics.
MedLine Citation:
PMID:  3203697     Owner:  NLM     Status:  MEDLINE    
Serum prolactin (PRL), luteinizing hormone (LH) and testosterone (T) levels were estimated in a group of 30 male paranoid schizophrenics before and after 4 weeks treatment with chlorpromazine and/or trihexyphenidyl, and in a group of 14 healthy male individuals. After treatment with chlorpromazine (100 mg t.i.d., p.o.), 10 patients presented a significant increase in serum PRL values and a significant decrease in serum T values. A significant increase in serum PRL values was also found in 10 patients who were treated with chlorpromazine (100 mg t.i.d., p.o.) plus trihexyphenidyl (5 mg t.i.d., p.o.). No significant difference in any of the investigated endocrine parameters was detected in 10 patients after 4 weeks administration of trihexyphenidyl (5 mg t.i.d., p.o.). Following chlorpromazine treatment with or without concomitant administration of trihexyphenidyl, 20 patients showed a significant increase in serum PRL levels and a significant decrease in serum LH and T levels.
P Rinieris; J Hatzimanolis; M Markianos; C Stefanis
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European archives of psychiatry and neurological sciences     Volume:  237     ISSN:  0175-758X     ISO Abbreviation:  Eur Arch Psychiatry Neurol Sci     Publication Date:  1988  
Date Detail:
Created Date:  1989-02-09     Completed Date:  1989-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8411522     Medline TA:  Eur Arch Psychiatry Neurol Sci     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  189-93     Citation Subset:  IM    
Department of Psychiatry, Athens University Medical School, Eginition Hospital, Greece.
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MeSH Terms
Chlorpromazine / administration & dosage*
Chronic Disease
Drug Therapy, Combination
Gonadal Steroid Hormones / blood*
Luteinizing Hormone / blood
Prolactin / blood
Schizophrenia, Paranoid / blood,  drug therapy*
Testosterone / blood
Trihexyphenidyl / administration & dosage*
Reg. No./Substance:
0/Gonadal Steroid Hormones; 144-11-6/Trihexyphenidyl; 50-53-3/Chlorpromazine; 58-22-0/Testosterone; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone

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