Document Detail

Effects of 4-tert-octylphenol on initiation and maintenance of pregnancy following oral administration during early pregnancy in rats.
MedLine Citation:
PMID:  11275424     Owner:  NLM     Status:  MEDLINE    
4-tert-Octylphenol (OP) is an alkylphenol that is an intermediate in the production of alkylphenol ethoxylates. OP has been reported to be the most potent estrogenic alkylphenol in vitro. In the present study, the effects of OP on initiation and maintenance of pregnancy were investigated in rats. Inseminated female rats were orally given OP at 0,15.6,31.3,62.5 and 125 mg/kg on day 0 through day 8 of pregnancy. Female rats were sacrificed on day 20 of pregnancy, and pregnancy outcome was determined. Decreases in body weight gain and food consumption on days 0-9 were found at 31.3 mg/kg and above, and at 15.6 mg/kg and above, respectively. The pregnancy rate was not adversely affected by OP administration during early pregnancy even at 125 mg/kg. The incidence of post-implantation loss per litter at 31.3 mg/kg and above was significantly higher than that in the control group. The body weights of live fetuses in the OP-treated groups were not significantly different from those in the control group. No increase in the incidence of fetuses with external malformations was found in any OP-treated group. We concluded that OP during early pregnancy caused post-implantation embryonic loss at doses that showed maternal toxicity.
A Harazono; M Ema
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicology letters     Volume:  119     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-29     Completed Date:  2001-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  79-84     Citation Subset:  IM    
National Institute of Health Sciences, Osaka Branch, 1-1-43 Hoenzaka, Chuo-ku, 540-0006, Osaka, Japan.
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MeSH Terms
Body Weight
Phenols / administration & dosage,  toxicity*
Pregnancy Outcome
Rats, Wistar
Reproduction / drug effects*
Surface-Active Agents / administration & dosage,  toxicity*
Uterus / drug effects,  physiology
Reg. No./Substance:
0/Phenols; 0/Surface-Active Agents; 140-66-9/4-tert-octylphenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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