Document Detail


Effects of 4-deoxypyridoxine on the isovolumic perfused rat heart: influence of oxygenation and glucose availability.
MedLine Citation:
PMID:  3441156     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The study was performed with isolated perfused isovolumic rat hearts. After a 40 min stabilization period, the effect of 4-deoxypyridoxine (DOP) 10(-5) M was studied with 3 Glc concentrations: 0, 3.3 and 11 mM. DOP was perfused during a 20 min normoxic or anoxic period followed by 40 min of normal perfusion. During normoxia with 11 mM Glc, DOP decreased the contracture observed in the control group. With 0 mM Glc, DOP improved developed pressure and dP/dt+ without a decrease in glycogen stores. During anoxia followed by reoxygenation, a partial protection towards CK release was observed with DOP (3.3 mM Glc). Intracellular PLP levels were higher in the 11 mM Glc group than in the other groups with and without DOP, and DOP with 11 mM Glc increased PLP levels (DOP N2 vs. DOP O2). Glycogen stores increased with 11 mM Glc without DOP (O2 vs. N2), whereas they decreased with DOP without Glc (DOP N2 vs. N2). DOP could improve the yield in glycogenolysis in normoxia and might activate mitochondrial anaerobic metabolism during anoxia.
Authors:
M Lorenzato; H Millart; O Albert; M Aurousseau
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Methods and findings in experimental and clinical pharmacology     Volume:  9     ISSN:  0379-0355     ISO Abbreviation:  Methods Find Exp Clin Pharmacol     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1988-04-15     Completed Date:  1988-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7909595     Medline TA:  Methods Find Exp Clin Pharmacol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  649-56     Citation Subset:  IM    
Affiliation:
Laboratoire de Pharmacologie, Faculté de Pharmacie, Reims, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Glucose / metabolism,  physiology*
Glycogen / metabolism
Heart / drug effects*
Male
Myocardial Contraction / drug effects
Oxygen / physiology*
Perfusion
Pyridoxal Phosphate / metabolism
Pyridoxine / analogs & derivatives*,  antagonists & inhibitors*,  pharmacology
Rats
Rats, Inbred Strains
Chemical
Reg. No./Substance:
50-99-7/Glucose; 54-47-7/Pyridoxal Phosphate; 61-67-6/4-deoxypyridoxine; 65-23-6/Pyridoxine; 7782-44-7/Oxygen; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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