| Effects of 4 beta-adrenoceptor blocking drugs on blood pressure and exercise heart rate in hypertension. | |
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MedLine Citation:
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PMID: 38965 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of 4 beta-adrenoceptor blocking drugs on blood pressure and on exercise tachycardia were compared in a within-patient study of patients with uncomplicated essential hypertension. Twelve patients were treated with propranolol, practolol and atenolol and 7 of the same patients also received oxprenolol. Each patient received each drug separately, withdrawing each drug before starting the next, and each patient was titrated to the lowest attainable blood pressure and heart rate with each compound. All 4 drugs caused reductions in both systolic and diastolic blood pressure and in the heart rate induced by exercise. The maximum reduction by each drug in both systolic and diastolic blood pressure was the same. There were small but significant differences in the effects on heart rate between those drugs which had intrinsic sympathomimetic activity and those which did not have this property. |
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Authors:
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J D Harry; M F Knapp; R J Linden; J B Stoker; C Newcombe |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: European journal of cardiology Volume: 10 ISSN: 0301-4711 ISO Abbreviation: Eur J Cardiol Publication Date: 1979 Aug |
Date Detail:
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Created Date: 1979-11-29 Completed Date: 1979-11-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0404054 Medline TA: Eur J Cardiol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 131-41 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology,
therapeutic use* Adult Atenolol / therapeutic use Blood Pressure / drug effects* Depression, Chemical Female Heart Rate / drug effects* Humans Hypertension / drug therapy* Male Middle Aged Oxprenolol / therapeutic use Practolol / therapeutic use Propranolol / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 29122-68-7/Atenolol; 525-66-6/Propranolol; 6452-71-7/Oxprenolol; 6673-35-4/Practolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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