Document Detail

Effects of 3-hydroxybutyrate on the hypoxic and reoxygenated atria from fed and fasted rats.
MedLine Citation:
PMID:  9542775     Owner:  NLM     Status:  MEDLINE    
When exposed to hypoxia, the isolated atria from fed rats released lactate into the medium and underwent a decline of the peak developed tension and pacemaker frequency. The atria from 24-h fasted rats showed a rise in the resting tension together with a greater decline of the pacemaker rate and a lower lactate output than those from fed rats. The exposure to 5 mM 3-hydroxybutyrate caused only a small and brief decline in the pacemaker rate in the fed rats atria indicating that ketone bodies are able to exert only a minor detrimental effect on the hypoxic atria. Since the lactate output remained unaffected, this effect cannot be ascribed to a lowering in the energy supply from anaerobic glycolysis. On the contrary, 3-hydroxybutyrate improved the post-hypoxic recovery of the peak tension in the atria from fasted rats. This finding may be reflecting an anaplerotic role of 3-hydroxybutyrate, thus suggesting that in addition to glucose a second substrate is needed to meet the energy demand in the reoxygenated atria from fasted rats.
A Varela; G Testoni; M Carregal; V Dalamon; E A Savino
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Revista española de fisiología     Volume:  53     ISSN:  0034-9402     ISO Abbreviation:  Rev. Esp. Fisiol.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-05-20     Completed Date:  1998-05-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404475     Medline TA:  Rev Esp Fisiol     Country:  SPAIN    
Other Details:
Languages:  eng     Pagination:  377-81     Citation Subset:  IM    
Cátedra de Fisiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Argentina.
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MeSH Terms
3-Hydroxybutyric Acid
Atrial Function
Cell Hypoxia / drug effects
Eating / physiology
Fasting / physiology
Heart Atria / drug effects*,  metabolism
Heart Rate / drug effects
Hydroxybutyrates / pharmacology*
Myocardial Contraction / drug effects
Oxygen / metabolism*
Rats, Wistar
Reg. No./Substance:
0/Hydroxybutyrates; 300-85-6/3-Hydroxybutyric Acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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