Document Detail


Effects of 3-chloromethylthiochromone-1,1-dioxide on nucleic acid, protein, and aerobic and anaerobic metabolism of Ehrlich ascites tumor cells.
MedLine Citation:
PMID:  7120085     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
3-Chloromethylthiochromone-1,1-dioxide was observed to be a potent inhibitor of Ehrlich ascites carcinoma growth and a moderate inhibitor of P-388 lymphocytic leukemia growth at 10 mg/kg/day. Preliminary in vitro studies showed that the agents significantly inhibited RNA and DNA synthesis in Ehrlich ascites cells. In vivo studies after dosing on Days 6, 7, and 8 demonstrated the same reductions in nucleic acid synthesis and a moderate reduction in protein synthesis. The primary site of nucleic acid synthesis, which was blocked by 3-chloromethylthiochromone, was at orotidine monophosphate decarboxylase in the primidine pathway. Other enzymes, in anaerobic and aerobic glycolysis, which were blocked include hexokinase, phosphofructokinase, succinic and alpha-ketoglutarate dehydrogenases, as well as States 3 and 4 of oxidative phosphorylation.
Authors:
M H Holshouser; L J Loeffler; I H Hall
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  71     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-12-02     Completed Date:  1982-12-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  857-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aerobiosis
Anaerobiosis
Animals
Antineoplastic Agents / pharmacology*
Carcinoma, Ehrlich Tumor / enzymology,  metabolism*
Citric Acid Cycle / drug effects
Cyclic S-Oxides / pharmacology*
DNA, Neoplasm / biosynthesis
Glycolysis / drug effects
Male
Mice
Neoplasm Proteins / biosynthesis
Orotidine-5'-Phosphate Decarboxylase / antagonists & inhibitors
Oxidative Phosphorylation / drug effects
RNA, Neoplasm / biosynthesis
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Cyclic S-Oxides; 0/DNA, Neoplasm; 0/Neoplasm Proteins; 0/RNA, Neoplasm; 77694-48-5/3-(chloromethyl)thiochromone 1,1-dioxide; EC 4.1.1.23/Orotidine-5'-Phosphate Decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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