Document Detail


Effects of ω-3 Fish Oil Lipid Emulsion Combined With Parenteral Nutrition on Patients Undergoing Liver Transplantation.
MedLine Citation:
PMID:  22421017     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The effect of parenteral nutrition (PN) support supplemented with ω-3 fatty acids was investigated in a randomized, controlled clinical trial at the Affiliated Drum Tower Hospital, Medical School of Nanjing University. Materials and Methods: Ninety-eight patients with the diagnosis of end-stage liver disease or hepatic cellular carcinoma were admitted for orthotopic liver transplantation at the Affiliated Drum Tower Hospital. The patients were randomly divided into 3 groups: diet group (n = 32), PN group (n = 33), and polyunsaturated fatty acid (PUFA) group (n = 33). Patients in the PN and PUFA groups received isocaloric and isonitrogenous PN for 7 days after surgery. Venous heparin blood samples were obtained for assay on days 2 and 9 after surgery. A pathological test was performed after reperfusion of the donor liver and on day 9. RESULTS: Alanine aminotransferase levels were improved significantly by PUFA treatment compared with traditional PN support (P < .05). Compared with the results on day 9 in the PN group, a significant difference was seen in the extent of increase of the prognostic nutrition index and prealbumin in the PUFA group. The pathological results also showed that ω-3 fatty acid supplementation reduced hepatic cell injury. PUFA therapy also decreased the incidence of infectious morbidities and shortened the posttransplant hospital stay significantly. Conclusion: Posttransplant PN support can greatly improve metabolism of protein and nutrition states of patients. ω-3 fatty acid-supplemented PN significantly reduces injury of the transplanted liver, decreases the incidence of infectious morbidities, and shortens posttransplant hospital stay. (JPEN J Parenter Enteral Nutr. XXXX;xx:xx-xx).
Authors:
Xinhua Zhu; Yafu Wu; Yudong Qiu; Chunping Jiang; Yitao Ding
Related Documents :
3298087 - Cefotetan in the treatment of serious intra-abdominal sepsis: a controlled clinical trial.
9655157 - Peritoneal dialysis in children under 5 years of age.
2085577 - Exit-site care and exit-site infection in continuous ambulatory peritoneal dialysis (ca...
22483487 - Partial splenic artery embolization for thrombocytopenia and uncontrolled massive ascit...
24183347 - Utilizing preoperative 20-minute pad testing with vaginal gauze packing for indicating ...
16239787 - Mini-incision total knee arthroplasty can increase risk of component malalignment.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-14
Journal Detail:
Title:  JPEN. Journal of parenteral and enteral nutrition     Volume:  -     ISSN:  0148-6071     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7804134     Medline TA:  JPEN J Parenter Enteral Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Medical School of Nanjing University, Nanjing, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Morphology of single olivocerebellar axons in the denervation-reinnervation model produced by subtot...
Next Document:  The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 ...