Document Detail

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on de novo fatty acid and cholesterol synthesis in the rat.
MedLine Citation:
PMID:  3185127     Owner:  NLM     Status:  MEDLINE    
The effects of 1, 5, 10 and 20 micrograms/kg dosages of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) upon de novo fatty acid and cholesterol synthesis in liver and adipose tissue were determined in pair-fed rats. The incorporation of tritium from 3H2O into tissue lipids was measured. Hepatic and adipose fatty acid synthetic rates (mumoles acetyl units g-1 hr-1) in the control groups were 19.6 +/- 4 and 75.7 +/- 18.5, respectively, and the liver cholesterol synthetic rate was 2.9 +/- 0.5. TCDD (1 microgram/kg) inhibited fatty acid synthesis in the liver and adipose tissue, by 44% and 41%, respectively, and the liver cholesterol synthesis was inhibited by 37%. The extent of these inhibitions increased with increasing dosages of TCDD. The effect of TCDD on sterol synthesis in adipose tissue could not be determined, because the tritium incorporation into the sterol fraction in this tissue was not detectable.
M R Lakshman; B S Campbell; S J Chirtel; N Ekarohita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lipids     Volume:  23     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-12-22     Completed Date:  1988-12-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  904-6     Citation Subset:  IM    
Lipid Research Laboratory, V.A. Medical Center, Washington, DC 20422.
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MeSH Terms
Adipose Tissue / drug effects,  metabolism
Body Weight / drug effects
Cholesterol / biosynthesis*
Dioxins / pharmacology*
Fatty Acids / biosynthesis*
Liver / drug effects,  metabolism
Organ Size / drug effects
Rats, Inbred Strains
Tetrachlorodibenzodioxin / pharmacology*
Reg. No./Substance:
0/Dioxins; 0/Fatty Acids; 1746-01-6/Tetrachlorodibenzodioxin; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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