Document Detail

Effects of 2200-m hypoxia on glucidic metabolism.
MedLine Citation:
PMID:  172924     Owner:  NLM     Status:  MEDLINE    
Rats exposed for different intervals (1, 3 and 6 hours, the first day, and then 6 hours a day for 9 days) to a 2200-m hypoxia presented metabolic changes demonstrating an anaerobic glucose utilization. Thus, in accordance with other authors, at different depressurization values the liver homogenate had increased lactate and pyruvate concentrations, decreased NAD and NADH2 concentrations and a decreased ATP formation, demonstrating the inefficient glucide metabolization. These modifications were evident in the first hours of depressurization, but did not occur under acclimatization during the 9 days of exposure. The LDH concentration remained practically unchanged, which might be explained by its explained by its excessive presence in relation to the normal exercise solicitation. A urinary hypercompensatory alkalinization was also recorded.
P Groza; J Boerescu; M Stefan; R Cârmaciu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiologie     Volume:  12     ISSN:  1011-6206     ISO Abbreviation:  Physiologie     Publication Date:  1975  
Date Detail:
Created Date:  1976-02-20     Completed Date:  1976-02-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7510964     Medline TA:  Physiologie     Country:  ROMANIA    
Other Details:
Languages:  eng     Pagination:  161-4     Citation Subset:  AIM; IM; S    
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MeSH Terms
Adenosine Triphosphate / metabolism
Anoxia / metabolism*
Carbohydrate Metabolism*
Glucose / metabolism
L-Lactate Dehydrogenase / metabolism
Lactates / metabolism
Liver / metabolism
Liver Glycogen / metabolism
NAD / metabolism
Pyruvates / metabolism
Reg. No./Substance:
0/Lactates; 0/Liver Glycogen; 0/Pyruvates; 50-99-7/Glucose; 53-84-9/NAD; 56-65-5/Adenosine Triphosphate; EC Dehydrogenase

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