Document Detail

Effects of 2-nicotinamidoethyl nitrate on the cardiovascular system.
MedLine Citation:
PMID:  160469     Owner:  NLM     Status:  MEDLINE    
Using the dog as experimental animal, effects on the cardiovascular system of a new vasodilator, 2-nicotinamidoethyl nitrate (SG-75), were studied. In the heart-lung preparation, the compound produced a dose-dependent increase in the coronary blood flow, which was associated with only a minimal increase in the myocardial oxygen consumption. There was essentially no change in the myocardial function. The myocardial redox potential was shifted to more positive values. In the isolated perfused heart preparation (Langendorff's preparation), SG-75 produced a dilatation of only the small resistive arterioles. However, it produced a dilatation of the large conductive artery in underperfused myocardium. SG-75 produced a significant increase in the cerebral venous outflow, associated with an increase in the cerebro-spinal fluid pressure. It produced a reducation of the venous return, which was especially prominent in the lower half of the body. In the isolated smooth muscle preparation of the coronary artery, high-doses of SG-75 induced calcium antagonistic effects and produced a relaxation of the lanthanum contracture.
Y Nakagawa; K Takeda; Y Katano; T Tsukada; T Kitagawa; T Otorii; S Imai
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  20     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1979 Nov 
Date Detail:
Created Date:  1980-03-27     Completed Date:  1980-03-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  881-95     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects
Cardiovascular System / drug effects*
Cerebrovascular Circulation / drug effects
Coronary Circulation / drug effects
Coronary Vessels / drug effects
Energy Metabolism
Heart / drug effects
Heart Rate / drug effects
Muscle, Smooth, Vascular / drug effects
Myocardium / metabolism
Niacinamide / analogs & derivatives*,  pharmacology
Nitrates / pharmacology
Nitroglycerin / pharmacology
Vasodilator Agents / pharmacology*
Veins / drug effects
Reg. No./Substance:
0/Nitrates; 0/Vasodilator Agents; 55-63-0/Nitroglycerin; 98-92-0/Niacinamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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