| Effects of 2-nicotinamidoethyl nitrate on the cardiovascular system. | |
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MedLine Citation:
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PMID: 160469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Using the dog as experimental animal, effects on the cardiovascular system of a new vasodilator, 2-nicotinamidoethyl nitrate (SG-75), were studied. In the heart-lung preparation, the compound produced a dose-dependent increase in the coronary blood flow, which was associated with only a minimal increase in the myocardial oxygen consumption. There was essentially no change in the myocardial function. The myocardial redox potential was shifted to more positive values. In the isolated perfused heart preparation (Langendorff's preparation), SG-75 produced a dilatation of only the small resistive arterioles. However, it produced a dilatation of the large conductive artery in underperfused myocardium. SG-75 produced a significant increase in the cerebral venous outflow, associated with an increase in the cerebro-spinal fluid pressure. It produced a reducation of the venous return, which was especially prominent in the lower half of the body. In the isolated smooth muscle preparation of the coronary artery, high-doses of SG-75 induced calcium antagonistic effects and produced a relaxation of the lanthanum contracture. |
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Authors:
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Y Nakagawa; K Takeda; Y Katano; T Tsukada; T Kitagawa; T Otorii; S Imai |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Japanese heart journal Volume: 20 ISSN: 0021-4868 ISO Abbreviation: Jpn Heart J Publication Date: 1979 Nov |
Date Detail:
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Created Date: 1980-03-27 Completed Date: 1980-03-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401175 Medline TA: Jpn Heart J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 881-95 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Cardiovascular System / drug effects* Cerebrovascular Circulation / drug effects Coronary Circulation / drug effects Coronary Vessels / drug effects Dogs Energy Metabolism Female Heart / drug effects Heart Rate / drug effects Male Muscle, Smooth, Vascular / drug effects Myocardium / metabolism Niacinamide / analogs & derivatives*, pharmacology Nitrates / pharmacology Nitroglycerin / pharmacology Vasodilator Agents / pharmacology* Veins / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Nitrates; 0/Vasodilator Agents; 55-63-0/Nitroglycerin; 98-92-0/Niacinamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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